Master in Biology

Course outline

This course offers a general view of the new advances related to the control of gene expression, genome structure and organization across the tree of life: bacteria, lower (yeast, protozoans) and higher (plants, mammalian) eukaryotes, and viruses.

It focuses on the analysis and comprehension of the mechanisms underlying gene expression. This includes in vitro and in vivo approaches as well as the newest developments of gene editing.

A specific emphasis will be given to new aspects of gene regulation at a transcriptional and post-transcriptional level in eukaryotic cells (animals and plants). In particular, the role of the epigenome involving DNA methylation, histones and histone variants, long and short non-coding RNAs will be illustrated.

Through a broad range of model organisms (human, mouse, plants, yeast, bacteria…) the questions that are addressed in the fields of evolution, cell differentiation and development will be presented. The mechanisms used by parasites and viruses to infect host cells will be analyzed as well.

Through these different models, we will see that although specificities exist in the control of gene expression and the way organisms adapt to their environment, common mechanisms and common themes do exist throughout the tree of life.

Key words: Transcriptional and post-transcriptional gene expression regulation, chromosome structure, RNA interference, gene editing, genomes evolution and adaptation, infection, non-coding genomes, Genetics and Epigenetics.

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Course outline

• Biocatalysis

         Basis in Enzymes cofactors and vitamins

         Cofactors involved in group transfer

         Cofactors involved in redox reaction

         Cofactors and chemical origin of life

• Biological Chemistry of Oxygen

          Chemistry of O₂

          Defense mechanism, detoxification of reactive oxygen species (ROS)

          Role of ROS in physio-pathology

          Regulation, sensing mechanism

          Cellular sources of ROS.

•  Membrane Biochemistry

         Lipids, Membrane and Rafts

         Membrane proteins: synthesis and topology

         Membrane proteins and detergent biochemistry

         Receptors

         Transporters

         Vesicular trafficking.

•   Biochemistry of viral infection and immunity

         Membrane fusion

         Membrane budding

         Biochemistry of innate factors

•   Extracellular Biochemistry: GAGs

         Extracellulaire matrices

         Glycosaminoglycans (GAG): biosynthesis and catabolism

         GAG: biological activities

         GAG: pathology and applications

•   Methods of study

         Molecualr factory characterisation : cryoelectron microscopy

         Imaging complexes, location and dynamic in cellulo

This module brings strong background (relative to oxidative stress) to the Unit “Experimental Approaches in Biology”

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The main objective of this module is to learn how to design, perform and interpret experiments but also to present these experiments in a written report and orally. This module develops many personal and professional skills such as reasoning expertise, analysis ability, adaptation and curiosity. It also gives students the opportunity to learn how to communicate around their scientific results and to argue their experimental choices. Beyond this main objective, this module provides an integrated and transdisciplinary vision of biology and allows students to break down the barriers of disciplinary learning and to give sense to their academic knowledge. To achieve these goals we have set up a creative pedagogy based on the use of varied and innovative strategies.

Tutoring sessions (around 3h/student) will help you to define your project, to formulate hypotheses and to design the experimental strategy. The experiments will be performed during 3 weeks of practical courses.

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During the second semester of the first year of the master’s degree, students discover the research activity by participating in a lab internship. The official period of this internship is limited to 44 days.

For their internship, the students may choose laboratories from any university or institution in France or other countries. Students are encouraged to contact and visit as many labs as needed in order to choose the project and lab environment that fit with their personal interest.

In addition to a strong scientific background, the students must be motivated, serious, reliable, on time, independent, open to discussion, curious and self-organized.

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The aim of this course is to study development and cell differentiation as the result of multiple interactions of genetic and epigenetic regulations organized into networks. In this context, the module is in direct and logical continuity with the master 1 module “Molecular Genetics and Epigenetics”. This “Development and Differentiation” module will take examples from a wide range of organisms including prokaryotes, protists (protozoa), and higher eukaryotes such as plants and animals.

The module is divided into three major themes: Gametogenesis and Early Development, Organogenesis and Tissue Differentiation and finally, Cell Differentiation and Environment with the concern to always draw examples from the diversity represented along the tree of life.

Together with the module “Molecular Genetics and Epigenetics”, this course will give an integrated overview of cell differentiation and development and how these activities are orchestrated and regulated by genetic and epigenetic factors. This will be illustrated by examples coming from a wide range of organisms. Therefore, this course is strongly recommended as a preparation to the PHEDD M2 program and would also be grounding to other M2 programs such as NN and IMID.

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The course is organized into two parts:

The first one is devoted to the understanding of the integrated metabolism in mammals under physiological conditions, with a particular emphasis on the interactions between the different organs involved in homeostasis.

The second one is focused on the dysregulations of the physiological pathways involved in energy homeostasis. In this context, the main metabolic disorders, such as diabetes, metabolic syndrome and obesity are discussed, as well as their main co-morbidities : atherosclerosis and coronary heart disease.

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The objective of this course is to acquire the fundamental knowledge necessary to understand key mechanisms of cancer development. This course includes a set of lectures on alterations of cellular and molecular mechanisms that are responsible for the cancer pathophysiology. These modified cellular functions include for example the cell division, apoptosis, gene expression, stem cells, angiogenesis and degradation of the extracellular matrix...  The fundamental notions will be illustrated via their implications in diagnosis and therapeutics. The publication analysis will allow emphasizing the medical interest.

To which kind of program can you apply when taking this course?

-  Any kind of Master 2 program.

- The module is particularly recommended to the students interested in the PHEDD program.

- Medical Students (MED)

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This course will allow a better understanding of the anatomical, neurochemical, neurobiological and neurophysiological basis of normal and pathological behaviors (anxiety, addiction, stress). This course will contain the following lectures:

-Neurotransmission in the central nervous system: basis and main systems (lectures, 13h)

-Functional neuro-anatomy of the cerebral cortex (lecture, 3h)

-Interest of the functional neuro-imagery in the study of behaviors (lecture, 4h; tutorial, 2h)

-EEG: a tool for the study of the awake/sleep behavior (tutorial, 2h)

-Study of the neurobiological basis of the behavior: behavioral tests in human and animal (tutorial, 2h)

-Study and neurobiological model of the emotional processing (lecture, 4h)

-Physiopathology of anxiety, stress and depression (lecture, 3h)

-Neurobiology of drug addiction (lectures, 7h)

-Alterations in visuo-spatial orientation and obsessive-compulsive disorders (lecture, 2h)

-Behavioral tests in animal (practical, 4h)

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The course will aim at giving, through examples of existing drugs, an overview of the strategies used for drug development, from the identification of a molecular target to the marketing of an active product. The course will include presentations about enzyme catalysis and enzyme kinetics with particular emphasis on inhibition, on the problems faced when developing a drug and on computational approaches used in this field. The course will include sessions of computer analysis of enzyme kinetic data and of tutorials of molecular modeling.

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-       Integrated function of the immune system

-       Continuum between the innate- and the adaptive immune system

-       Physiological modes of action of the immune system in infectious diseases and cancer

-       Immune system regulation

-       Immune system dysfunction and therapeutic modes of action: examples of developing applications.

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Course outline

Lectures:

1)    Introduction to infectious diseases (1.5 h) CM

2)    Parasites: bases of the pathogenicity and host / parasite interactions

-       Make yourself at home: remodeling of the host cell by Plasmodium falciparum (1.5 h) CM

-       Schistosoma spp (1.5 h) HP

-       Neglected tropical diseases, selected examples:

Leishmanioses (3 h) CM

Lymphatic filariosis or foodborne trematodiases or cysticercosis (1.5 h) CM

3)    Pathogenic bacteria: bases of the pathogenicity and host / bacteria interactions

-       Borrelia burgdorferi, the infectious agent of Lyme disease: evasion from the immune system (1.5 h) ASP

-       Pathogenicity of Vibrio cholerae, the infectious agent of cholera (1.5 h) ASP

-       Gastric ulcer and gastric cancer: the role of Helicobacter pylori (1.5 h) ASP

-       Lung diseases: Pseudomonas aeruginosa or Mycobacterium tuberculosis (1.5 h) CV

-       Pseudomonas aeruginosa: model of experimental evolution (1.5 h) CV

-       Bacteria of the digestive tract: Enterohemorrhagic Escherichia coli, Shigellae, Listeria monocytogenes (3 h) TH

-       Life within a vacuole: Francisella, Salmonella, Chlamydia (3 h) CM

4)    Viruses: bases of the pathogenicity and host cell / virus interactions

-       Negative RNA viruses: Influenza virus, Rabies, Measles, Ebola (7.5 h) RR and MJ

-       Virus and cancers (1.5h) PM

-       HIV-1: life cycle, entry and budding, vaccine development (3 h) WW

Tutorials: 15h

Analysis of scientific publications to illustrate different aspects of the course

Training to the terminal exam: examples of previous exams

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Course outline

In this course we will review the organization of the CNS and the functions related to the different parts of the brain. We will describe pathologies that affect specifically these parts of the CNS and the consequence of such diseases. Furthermore, we will describe the basis of psychopharmacology by analysis the therapeutic basis of the most common compounds used to cure psychiatric and neurodegenerative diseases.

During the tutorials, students will present a scientific article related to the topics presented during the lectures.

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The course will present the experimental strategies used to produce macromolecular samples for biophysical, structural studies and biotechnical applications, from bioinformatics analysis to recombinant protein expression systems, automation (robotics), purification and engineering and measurement of sample quality. Expected competences acquired by the students: expertise in bioinformatic analysis of macromolecule sequence and structure, understanding methods and strategies used to express and purify macromolecules, expertise in experimental methods used for sample quality control, practical experience on platforms on the EPN Campus.

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Course outline

Thematic of the lectures (25.5h):

- Structure of bacterial chromosomes (3h)

- Regulation of bacterial gene expression and bacterial genomics (sigma factors, sRNA; 6h)

- Bacterial cytoskeleton (1,5h)

- Global regulation of bacterial transcription (DNA topology and stringent response; 9h)

- Bacterial diversity and the new tree of life (3h)

- Plasticity of bacterial genomes (mobile genetic elements; 3h)

Tutorials (18h= 12x1.5h):

Before each session, students have to read one scientific paper on topics related to the lectures and its content (methodologies, results) is then discussed during the 1.5h tutorial.

Format of the course

Exam requirements

Oral exam: students have to prepare an oral synthesis of one scientific paper.

Synthesis: students have to prepare a written synthesis of one scientific paper.

Final exam: students have to analyse figures from one or two scientific papers.

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The goal of this course is to apprehend the latest findings about the cellular and molecular mechanisms of synaptic plasticity and the causes of their impairment in neurodegenerative diseases with a special emphasis on Alzheimer’s disease.

• What makes the electric      signal? The chemical synapse.
• The glutaminergic synaps: plasticity and memory. Regulation of neurotransmitter disease, of post-synaptic currents, modulation of the expression of pre-and post-synaptic receptors.
• Traffic and diffusion of synaptic receptors
• Genetic and molecular causes of Alzheimer’s disease: presinilins, APP, ApoE. Fronto-temporal dementia.

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Des enseignements explicatifs présentent l’Entreprise sous un angle systémique. Des rencontres avec les professionnels du recrutement permettent de comprendre les attentes des entreprises. Chaque participant choisit un métier dont il sera l’ambassadeur pendant ce cours.

Notions traitées :

Comprendre le fonctionnement d’une entreprise dans son environnement économique local, national et international.

Comprendre les clés du bon fonctionnement d’une entreprise.

Formes d’entreprises et d’organisations.

Métiers associés aux fonctions des entreprises.

Savoir parler des compétences lors d’une recherche de stage ou d’un recrutement.

Se projeter dans les métiers visés.

Participation d’intervenants professionnels du recrutement.

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The course starts with an introductory lecture that describes how scientific projects are usually performed. Major points discussed are:

1)    Structure and functioning of a scientific team („From Einstein to Frankenstein – what makes a modern scientist“)

2)    Scientific literature (critical reading of publications, building blocks of a publication, the „hidden“ information)

3)    The „value“ of a publication (impact factor and its consequences; ethics in publishing)

4)    Project planning and funding proposals (including funding agencies and fellowships)

5)    Financial and structural resources for a scientific project

The students will provide a short initial 10 min presentation of their master project summarizing the field of study, the topic and the project idea followed by 5 min of group discussion identifying the major technological and scientific questions. These will be discussed and explained in detail in subsequent tutorials.

The final goal for each student is to prepare a 4-page proposal on his/her future S4 internship and a potential consecutive PhD project in which he/she describes the rationale and strategy of the project, the research axes, the expected results and alternative strategies in case the original project idea turns out to be not feasible. The students will receive help for the preparation of this project by their lab supervisor (understanding of the subject, feasibility of the proposed experiments) and of regular discussions with the group of students.

The mid-term exam consists in a 30 min oral presentation that summarizes the bibliographic background of the proposal and presents the main technical aspects, followed by questions from the reviewing committee (researchers and faculty members), who will test the understanding of the project.

The final exam consists in:

- a 4-pages written proposal

- a 20 min discussion with the reviewing committee who will test the understanding of the project as well as the scientific culture of the candidate.

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Course outline

CM: To provide a comprehensive overview of cancer from basic research to clinical trials: cancer physiopathology; cancer metabolism; proteomics; circadian rhythm and cancer cell characteristics; development of new anti-cancer drugs; imaging in cancer disease.

TD: How to analyze a scientific article critically?

To provide a comprehensive overview of cancer from basic research to clinical trials.

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Course outline

The lectures present the basic methodology and some advanced techniques used for high throughput in vitro small molecule drug discovery. The principles and statistical methods used for assay optimization and validation will also be explained.

I. Molecular biology, Biochemistry and Protein expression

II. Proteomic analysis; Mass spectrometry

III. Lab-chips and Cell-chips

IV. Structural biology: Crystallogenesis and Crystallization; RMN

V. Combinatory chemistry

Format of exams:  Oral exam (at the end of December) and Research project (at the beginning of January)

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Course outline

 At the end of the course, the students should be able to analyze a "omic" dataset. More precisely, they should be able.

1- to load, explore and summarize graphically a dataset.

2- to compute confidence interval estimates for proportions, means and variances.

3- to formulate hypotheses, compute tests statistics, interpret p-values and make practical decisions for the

standard parametric and non-parametric tests.

4- to adjust simple and multiple linear models, analyses of variance (anovas), logistic regression, Cox

model.

5- to select genes that explain a response variable by applying multiple testing approaches.

6- to analyze a data set of differential gene expression.

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Introduction

Science, academic research and entrepreneurship

Innovation

Intellectual properties & juridical forms of companies (in French language due to the specific aspects of the French law)

Marketing of innovation

Customer segmentation

Business development

Project management

Market research

Business plan

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The student will spend 6 months in a research team to work on a scientific project dealing with at least one of the fields covered by the Master 2 IMID program.

Finding the research team and the subject relies on the student.

A proposal for this internship should be sent to the module’s coordinator during the spring/early summer of the previous academic year for validation: It must fit to at least one of the fields covered by the Master 2 IMID program.

The student will be supervised in the lab by a researcher of the field.

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The course starts with an introductory lecture that describes how scientific projects are usually performed. Major points discussed are:

1)    Structure and functioning of a scientific team („From Einstein to Frankenstein – what makes a modern scientist“)

2)    Scientific literature (critical reading of publications, building blocks of a publication, the „hidden“ information)

3)    The „value“ of a publication (impact factor and its consequences; ethics in publishing)

4)    Project planning and funding proposals (including funding agencies and fellowships)

5)    Financial and structural resources for a scientific project

The students will provide a short initial 10 min presentation of their master project summarizing the field of study, the topic and the project idea followed by 5 min of group discussion identifying the major technological and scientific questions. These will be discussed and explained in detail in subsequent tutorials.

The final goal for each student is to prepare a 4-page proposal on his/her future S4 internship and a potential consecutive PhD project in which he/she describes the rationale and strategy of the project, the research axes, the expected results and alternative strategies in case the original project idea turns out to be not feasible. The students will receive help for the preparation of this project by their lab supervisor (understanding of the subject, feasibility of the proposed experiments) and of regular discussions with the group of students.

The mid-term exam consists in a 30 min oral presentation that summarizes the bibliographic background of the proposal and presents the main technical aspects, followed by questions from the reviewing committee (researchers and faculty members), who will test the understanding of the project.

The final exam consists in:

- a 4-pages written proposal

- a 20 min discussion with the reviewing committee who will test the understanding of the project as well as the scientific culture of the candidate.

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Descriptif

The course will present practical and theoretical aspects of the classical approaches used to determine the structure of macromolecules by X-ray crystallography and Nuclear Magnetic Resonance spectroscopy. The program of this course is described below:

  Part I - Crystallography - 20h

• Crystallization techniques                                                                            
• Crystal symmetry and space groups                                                                      
• Diffraction                                                                                                    
• Structure factors, reciprocal space etc                                                      
• Tutorial: Data treatment                                                                                          
• Phasing – MIR, SAD, MAD                                                                        
• Molecular replacement, crystallographic symmetry                                              
• Tutorial: MAD Phasing                                                                                              
• Tutorial: Molecular replacement                                                                             
• Refinement                                                                                                  
• Tutorial: Model building and refinement                                                                  
• Practical lab: Crystallization on a PSB platform                                                                 
• Practical lab: X-ray data collection on a ESRF beamline                                                  

    Part II – Nuclear Magnetic Resonance-20h

• NMR principles: active nuclei, magnetic field, radiofrequency excitation,
             return to equilibrium                                                                                     
• NMR observables in the spectra of biomolecules (chem. shift, scalar
             couplings,  linewidth)                                                                        
• NMR observables: measurement                                                               
• Practical lab on IBS-NMR platform: data collection
• The steps to structure determination: sample preparation, isotopic labeling
• The steps to structure determination: assignment   
• The steps to structure determination: extraction of structural parameters 
• Tutorial: Data analysis                                                                                 
• Structure calculation: principles                                                                              
• Practical lab: Protein structure calculation  

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The course aims at introducing the students to advance and modern methods in structural biology that integrate structural and/or dynamical information at different levels of resolution.  

- Structure of large biomolecular assemblies

•  Obtaining key information on large biomolecular assemblies and systems
•  Electron microscopy and tomography
•  NMR spectroscopy
• X-ray and neutron diffraction
• Hybrid approaches (combination of high- and low-resolution structural methods)
•  Structure of ribosome, signal recognition particle, viruses,…

- From macromolecules to the cell

•  High resolution optical microscopy
•  Atomic force microscopy
•  Correlative electron microscopy (combination of optical and electron microscopy)
•  Structure and dynamics of the cytoskeleton
•  Biology of flower …..

- Dynamics of biomolecular systems

•  Dynamics by NMR spectroscopy
•  Neutron spectroscopy
•  Molecular dynamic simulations
• Intrinsically disordered proteins

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The course will present new developments in the structural characterization of macromolecules and their applications in biology, as well as new major discoveries in structural biology. For each topic, the course will include a lecture by a specialist in the field that will provide an overview of the subject, of the current state of development and of the future prospects. The course will address topics such as time-resolved crystallography, solid-state NMR, molecular dynamics simulations, single molecule observation and manipulation, as well as recent examples of applications taken from the literature. Each topic will also include presentations of recent publications by the students.

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Course outline

The lectures present the basic methodology and some advanced techniques used for high throughput in vitro small molecule drug discovery. The principles and statistical methods used for assay optimization and validation will also be explained.

I. Molecular biology, Biochemistry and Protein expression

II. Proteomic analysis; Mass spectrometry

III. Lab-chips and Cell-chips

IV. Structural biology: Crystallogenesis and Crystallization; RMN

V. Combinatory chemistry

Format of exams:  Oral exam (at the end of December) and Research project (at the beginning of January)

Visit the full page about this course

Course outline

 At the end of the course, the students should be able to analyze a "omic" dataset. More precisely, they should be able.

1- to load, explore and summarize graphically a dataset.

2- to compute confidence interval estimates for proportions, means and variances.

3- to formulate hypotheses, compute tests statistics, interpret p-values and make practical decisions for the

standard parametric and non-parametric tests.

4- to adjust simple and multiple linear models, analyses of variance (anovas), logistic regression, Cox

model.

5- to select genes that explain a response variable by applying multiple testing approaches.

6- to analyze a data set of differential gene expression.

Visit the full page about this course

Visit the full page about this course

Introduction

Science, academic research and entrepreneurship

Innovation

Intellectual properties & juridical forms of companies (in French language due to the specific aspects of the French law)

Marketing of innovation

Customer segmentation

Business development

Project management

Market research

Business plan

Visit the full page about this course

The student will spend 6 months in a research team to work on a scientific project dealing with at least one of the fields covered by the Master 2 ISB program.

Finding the research team and the subject relies on the student.

A proposal for this internship should be sent to the module’s coordinator during the spring/early summer of the previous academic year for validation: It must fit to at least one of the fields covered by the Master 2 ISB program.

The student will be supervised in the lab by a researcher of the field.

Visit the full page about this course

Visit the full page about this course

Visit the full page about this course

The course starts with an introductory lecture that describes how scientific projects are usually performed. Major points discussed are:

1)    Structure and functioning of a scientific team („From Einstein to Frankenstein – what makes a modern scientist“)

2)    Scientific literature (critical reading of publications, building blocks of a publication, the „hidden“ information)

3)    The „value“ of a publication (impact factor and its consequences; ethics in publishing)

4)    Project planning and funding proposals (including funding agencies and fellowships)

5)    Financial and structural resources for a scientific project

The students will provide a short initial 10 min presentation of their master project summarizing the field of study, the topic and the project idea followed by 5 min of group discussion identifying the major technological and scientific questions. These will be discussed and explained in detail in subsequent tutorials.

The final goal for each student is to prepare a 4-page proposal on his/her future S4 internship and a potential consecutive PhD project in which he/she describes the rationale and strategy of the project, the research axes, the expected results and alternative strategies in case the original project idea turns out to be not feasible. The students will receive help for the preparation of this project by their lab supervisor (understanding of the subject, feasibility of the proposed experiments) and of regular discussions with the group of students.

The mid-term exam consists in a 30 min oral presentation that summarizes the bibliographic background of the proposal and presents the main technical aspects, followed by questions from the reviewing committee (researchers and faculty members), who will test the understanding of the project.

The final exam consists in:

- a 4-pages written proposal

- a 20 min discussion with the reviewing committee who will test the understanding of the project as well as the scientific culture of the candidate.

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Full lectures on cognitive, sensory, limbic and motor systems from expert contributors, e.g.:

-       Neural basis of language

-       Brain's rhythms: role and source

-       Neural basis of conscious and non-conscious processes

Full lectures on physiopathology of non-degenerative diseases from MD and PhD contributors, e.g.:

-       Epilepsy physiopathology

-       Schizophrenia physiopathology

-       OCD: new pathophysiological insights

-       Drugs addiction and neuro-adaptation: hijacking of the reward system

Each year, a full day congress will be organized on a particular field, coordinated with other M2 NN modules.

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• Alzheimer
• Parkinson
• Huntington
• Amyotrophic Lateral Sclerosis
• Multiple Sclerosis
• Trauma, Stroke

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The 3h lectures are given by specialists of the field working in Grenoble or in foreign univeristies. They will deal with the following subjects:

• Principle of electrophysiology
• Principle of calcium and voltage membrane potential imaging
• The use of transgenic mice and bi-photon microscopy to monitor the role of glial cells in the brain.
• Ischemia: Glutamate receptors and ischemia
• Of Microtubules and Mitochondria
• Stem cells in the CNS          
• Alzheimer’s disease: from the gene down to the synapse
• Huntington and axonal transport
• Htt links Neurodegeneration to CNS development

10h will be dedicated to presentations of scientific articles by students.

Each year, a full day congress will be organized on a particular field, coordinated with other M2 NN modules.

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Course outline

CM: To provide a comprehensive overview of cancer from basic research to clinical trials: cancer physiopathology; cancer metabolism; proteomics; circadian rhythm and cancer cell characteristics; development of new anti-cancer drugs; imaging in cancer disease.

TD: How to analyze a scientific article critically?

To provide a comprehensive overview of cancer from basic research to clinical trials.

Visit the full page about this course

Course outline

The lectures present the basic methodology and some advanced techniques used for high throughput in vitro small molecule drug discovery. The principles and statistical methods used for assay optimization and validation will also be explained.

I. Molecular biology, Biochemistry and Protein expression

II. Proteomic analysis; Mass spectrometry

III. Lab-chips and Cell-chips

IV. Structural biology: Crystallogenesis and Crystallization; RMN

V. Combinatory chemistry

Format of exams:  Oral exam (at the end of December) and Research project (at the beginning of January)

Visit the full page about this course

Course outline

 At the end of the course, the students should be able to analyze a "omic" dataset. More precisely, they should be able.

1- to load, explore and summarize graphically a dataset.

2- to compute confidence interval estimates for proportions, means and variances.

3- to formulate hypotheses, compute tests statistics, interpret p-values and make practical decisions for the

standard parametric and non-parametric tests.

4- to adjust simple and multiple linear models, analyses of variance (anovas), logistic regression, Cox

model.

5- to select genes that explain a response variable by applying multiple testing approaches.

6- to analyze a data set of differential gene expression.

Visit the full page about this course

Today, the term Epigenetics is used to describe the study of heritable changes in genome function that occur without a change in DNA sequence. This includes the way gene expression is passed from one cell to its progeny, how gene expression changes during the differentiation of one cell type into another, and how environmental factors can change the way genes are expressed.

Epigenetic regulation involves changes of chromatin structure. Interestingly, the mechanisms involved in epigenetic regulation, such as histone modifications, also participate in the transient changes of gene expression.

This course is therefore opened to all students with an interest in the control of gene expression. There are far-reaching implications of epigenetic research for plant and human biology and disease.

The different mechanisms involved in epigenetic regulation, and the different contexts involving epigenetic regulation will be presented.

- Actors involved in epigenetic regulation (role of histone modification, chromatin remodeling complex, histone variants, DNA methylation, small and long noncoding RNA),

- Contexts involving an epigenetic regulation (response to cell environment, cell differentiation, development)

- Implication in diseases

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I. LECTURES (20 hours)

1- Cardiac energy metabolism: energetic regulations; cardiac energy transfer

            - Bioenergetics and the role of oxygen in bioenergetics

            - Contraction in cardiovascular systems, compartmentalization and energy transfer

            - Modular organization of cardiac energy metabolism

            - Metabolic aspects of the Frank-Starling’s law in the heart

2- Recent progress in basic cardiovascular physiology

       - Heart and chronobiology

       - Heart rate and longevity

       - Cardiac conditioning (pre-conditioning, post-conditioning and remote conditioning)

       - Intracellular signaling pathways in vascular systems

       - Chronic exercise and vascular function

3- Mechanistic approaches in cardiovascular pathophysiology

       - Recent advances in cardiac pharmacology

       - Nutrition and cardiovascular risk

       - Cardiovascular consequences of obesity and insulin resistance

       - Oxidative stress and cardiovascular system

       - Strategies for prevention of vascular diseases: pharmacology and prophylaxis

       - Endothelial dysfunction in vascular pathologies

4- Vulnerable plaque

       - Evolution of the concept of coronary artery disease

-  Vulnerable plaque, a main problem of public health

-  New strategies for vulnerable plaque detection

-  Non-invasive imaging tools: nuclear medicine, ultrafast computed tomography, magnetic resonance imaging

II. TUTORIALS (20 hours

Analysis of scientific publications that illustrate different aspects of the lectures and oral presentations by the students (two to three presentations per student).

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This course will present the major issues related to the ageing processes and their consequences on longevity, in humans, animals and plants.

The main anatomical, histological, molecular and functional changes will be described in several major organs or systems (cardiovascular, nervous, pulmonary, muscular, immune, ...), together with some of the essential clinical problems of human ageing (fragility of elderly, neurodegenerative diseases, ..).

 The role of important actors of the ageing mechanisms, such as telomeres and mitochondria, will be addressed before a final presentation of the principal theories of ageing. Some data about stem cells and their roles will also be presented.

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Course outline

The main theme of this course is centred on how regulatory networks and specific patterns of gene expression shape development and have evolved in animal and plant kingdoms.

On the animal side, you will hear about basic concepts of early evolution of metazoan development and body plans in Arthropods, we will analyse the role of neural crest in vertebrate segmentation and head patterning, and discuss developmental mechanisms of evolutionary change.

On the Plant front, developmental genetics of plant speciation, evolution of flower development, and molecular mechanisms generating flower diversity and underlying plant domestication will be the major topics.

Overall, this Evo-Devo course will give an overview, through the examples of various developmental models, of how shaping/reshaping of genes and genomes drove the diversity represented along the tree of life and conducted to present-day organisms living on earth.

The teaching team consists of local, national and international specialists in their field who will present the topics they are passionate about.

Lectures (15)

1) General introduction (2 lectures)

What is Evo-Devo:

- Introduction to Evolution of Developmental Genes

- Evidences for evolution of developmental genes in animals and plants

2) Animal Evo-Devo (6 lectures)

- An overview of animal clades and patterns of Development

- Evolutionary dynamics of zygote gene activations

- Conservation of gene regulation circuits in Evolution

- Cranial ganglia patterning in vertebrate development

- Molecular basis of placodes development in Vertebrates

- Male genome reprogramming: What have the mice taught us?

3) Plant Evo-Devo (6 lectures)

- The Phylogeny of Chloroplasts

- Retrograde signalling networks in the regulation of development in eukaryotes

- The mysterious origin of the flowering plants

- Evolution of floral symmetry and epigenetics

- Combining next generation Evo-Devo with new model organisms to study plant-pollinator interactions.

- Plant Evolution and Domestication

4) Concluding/Overview lecture (1 lecture)

Plant and Animal Genome Plasticity in Evolution

Tutorials (12)

Tutorials consist in analyses of scientific publications by students. The articles are in direct connection to the lectures/seminars. They are given to the students a week in advance. Students highlight the messages of the articles via analysis of the main figures/results. They present the state-of-the-art and the objectives of the study as an introduction, then the approaches employed to answer the questions, the main results and their driven-conclusions, and finish with perspectives of the presented work. Article analysis is followed by a discussion with the Professor and all students of the class.

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Introduction

Science, academic research and entrepreneurship

Innovation

Intellectual properties & juridical forms of companies (in French language due to the specific aspects of the French law)

Marketing of innovation

Customer segmentation

Business development

Project management

Market research

Business plan

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The student will spend 6 months in a research team to work on a scientific project dealing with at least one of the fields covered by the Master 2 NN program.

Finding the research team and the subject relies on the student.

A proposal for this internship should be sent to the module’s coordinator during the spring/early summer of the previous academic year for validation: It must fit to at least one of the fields covered by the Master 2 NN program.

The student will be supervised in the lab by a researcher of the field.

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The course starts with an introductory lecture that describes how scientific projects are usually performed. Major points discussed are:

1)    Structure and functioning of a scientific team („From Einstein to Frankenstein – what makes a modern scientist“)

2)    Scientific literature (critical reading of publications, building blocks of a publication, the „hidden“ information)

3)    The „value“ of a publication (impact factor and its consequences; ethics in publishing)

4)    Project planning and funding proposals (including funding agencies and fellowships)

5)    Financial and structural resources for a scientific project

The students will provide a short initial 10 min presentation of their master project summarizing the field of study, the topic and the project idea followed by 5 min of group discussion identifying the major technological and scientific questions. These will be discussed and explained in detail in subsequent tutorials.

The final goal for each student is to prepare a 4-page proposal on his/her future S4 internship and a potential consecutive PhD project in which he/she describes the rationale and strategy of the project, the research axes, the expected results and alternative strategies in case the original project idea turns out to be not feasible. The students will receive help for the preparation of this project by their lab supervisor (understanding of the subject, feasibility of the proposed experiments) and of regular discussions with the group of students.

The mid-term exam consists in a 30 min oral presentation that summarizes the bibliographic background of the proposal and presents the main technical aspects, followed by questions from the reviewing committee (researchers and faculty members), who will test the understanding of the project.

The final exam consists in:

- a 4-pages written proposal

- a 20 min discussion with the reviewing committee who will test the understanding of the project as well as the scientific culture of the candidate.

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This course will present the major issues related to the ageing processes and their consequences on longevity, in humans, animals and plants.

The main anatomical, histological, molecular and functional changes will be described in several major organs or systems (cardiovascular, nervous, pulmonary, muscular, immune, ...), together with some of the essential clinical problems of human ageing (fragility of elderly, neurodegenerative diseases, ..).

 The role of important actors of the ageing mechanisms, such as telomeres and mitochondria, will be addressed before a final presentation of the principal theories of ageing. Some data about stem cells and their roles will also be presented.

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I. LECTURES (20 hours)

1- Cardiac energy metabolism: energetic regulations; cardiac energy transfer

            - Bioenergetics and the role of oxygen in bioenergetics

            - Contraction in cardiovascular systems, compartmentalization and energy transfer

            - Modular organization of cardiac energy metabolism

            - Metabolic aspects of the Frank-Starling’s law in the heart

2- Recent progress in basic cardiovascular physiology

       - Heart and chronobiology

       - Heart rate and longevity

       - Cardiac conditioning (pre-conditioning, post-conditioning and remote conditioning)

       - Intracellular signaling pathways in vascular systems

       - Chronic exercise and vascular function

3- Mechanistic approaches in cardiovascular pathophysiology

       - Recent advances in cardiac pharmacology

       - Nutrition and cardiovascular risk

       - Cardiovascular consequences of obesity and insulin resistance

       - Oxidative stress and cardiovascular system

       - Strategies for prevention of vascular diseases: pharmacology and prophylaxis

       - Endothelial dysfunction in vascular pathologies

4- Vulnerable plaque

       - Evolution of the concept of coronary artery disease

-  Vulnerable plaque, a main problem of public health

-  New strategies for vulnerable plaque detection

-  Non-invasive imaging tools: nuclear medicine, ultrafast computed tomography, magnetic resonance imaging

II. TUTORIALS (20 hours

Analysis of scientific publications that illustrate different aspects of the lectures and oral presentations by the students (two to three presentations per student).

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Today, the term Epigenetics is used to describe the study of heritable changes in genome function that occur without a change in DNA sequence. This includes the way gene expression is passed from one cell to its progeny, how gene expression changes during the differentiation of one cell type into another, and how environmental factors can change the way genes are expressed.

Epigenetic regulation involves changes of chromatin structure. Interestingly, the mechanisms involved in epigenetic regulation, such as histone modifications, also participate in the transient changes of gene expression.

This course is therefore opened to all students with an interest in the control of gene expression. There are far-reaching implications of epigenetic research for plant and human biology and disease.

The different mechanisms involved in epigenetic regulation, and the different contexts involving epigenetic regulation will be presented.

- Actors involved in epigenetic regulation (role of histone modification, chromatin remodeling complex, histone variants, DNA methylation, small and long noncoding RNA),

- Contexts involving an epigenetic regulation (response to cell environment, cell differentiation, development)

- Implication in diseases

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Course outline

The main theme of this course is centred on how regulatory networks and specific patterns of gene expression shape development and have evolved in animal and plant kingdoms.

On the animal side, you will hear about basic concepts of early evolution of metazoan development and body plans in Arthropods, we will analyse the role of neural crest in vertebrate segmentation and head patterning, and discuss developmental mechanisms of evolutionary change.

On the Plant front, developmental genetics of plant speciation, evolution of flower development, and molecular mechanisms generating flower diversity and underlying plant domestication will be the major topics.

Overall, this Evo-Devo course will give an overview, through the examples of various developmental models, of how shaping/reshaping of genes and genomes drove the diversity represented along the tree of life and conducted to present-day organisms living on earth.

The teaching team consists of local, national and international specialists in their field who will present the topics they are passionate about.

Lectures (15)

1) General introduction (2 lectures)

What is Evo-Devo:

- Introduction to Evolution of Developmental Genes

- Evidences for evolution of developmental genes in animals and plants

2) Animal Evo-Devo (6 lectures)

- An overview of animal clades and patterns of Development

- Evolutionary dynamics of zygote gene activations

- Conservation of gene regulation circuits in Evolution

- Cranial ganglia patterning in vertebrate development

- Molecular basis of placodes development in Vertebrates

- Male genome reprogramming: What have the mice taught us?

3) Plant Evo-Devo (6 lectures)

- The Phylogeny of Chloroplasts

- Retrograde signalling networks in the regulation of development in eukaryotes

- The mysterious origin of the flowering plants

- Evolution of floral symmetry and epigenetics

- Combining next generation Evo-Devo with new model organisms to study plant-pollinator interactions.

- Plant Evolution and Domestication

4) Concluding/Overview lecture (1 lecture)

Plant and Animal Genome Plasticity in Evolution

Tutorials (12)

Tutorials consist in analyses of scientific publications by students. The articles are in direct connection to the lectures/seminars. They are given to the students a week in advance. Students highlight the messages of the articles via analysis of the main figures/results. They present the state-of-the-art and the objectives of the study as an introduction, then the approaches employed to answer the questions, the main results and their driven-conclusions, and finish with perspectives of the presented work. Article analysis is followed by a discussion with the Professor and all students of the class.

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The course is designed to provide students with a broad introduction to cancer biology. Strong emphasis is on cancer genetics (genetic predisposition, gene transcription, DNA repair), epigenetics and functional genomics approaches – including use of genome editing, cell line and animal models and structural biology approaches – and the impact of these in research for deriving new insights into the basic mechanisms and treatment of cancer.

Teaching is interactive and relies on research seminars from experts in the field as well as personal reading and learning (webinars) by the students.

Focus is on developing strong critical analysis skills that can be applied generally to research.

Visit the full page about this course

This course will present the major issues related to the ageing processes and their consequences on longevity, in humans, animals and plants.

The main anatomical, histological, molecular and functional changes will be described in several major organs or systems (cardiovascular, nervous, pulmonary, muscular, immune, ...), together with some of the essential clinical problems of human ageing (fragility of elderly, neurodegenerative diseases, ..).

The role of important actors of the ageing mechanisms, such as telomeres and mitochondria, will be addressed before a final presentation of the principal theories of ageing. Some data about stem cells and their roles will also be presented.

Visit the full page about this course

Course outline

The main theme of this course is centred on how regulatory networks and specific patterns of gene expression shape development and have evolved in animal and plant kingdoms.

On the animal side, you will hear about basic concepts of early evolution of metazoan development and body plans in Arthropods, we will analyse the role of neural crest in vertebrate segmentation and head patterning, and discuss developmental mechanisms of evolutionary change.

On the Plant front, developmental genetics of plant speciation, evolution of flower development, and molecular mechanisms generating flower diversity and underlying plant domestication will be the major topics.

Overall, this Evo-Devo course will give an overview, through the examples of various developmental models, of how shaping/reshaping of genes and genomes drove the diversity represented along the tree of life and conducted to present-day organisms living on earth.

The teaching team consists of local, national and international specialists in their field who will present the topics they are passionate about.

Visit the full page about this course

Course outline

Today, the term “epigenetics” is used to describe the study of heritable changes in genome function that occur without a change in DNA sequence. This includes the way gene expression is passed from one cell to its progeny, how gene expression changes during the differentiation of one cell type into another, and how environmental factors can change the way genes are expressed. Epigenetic regulation involves changes of chromatin structure. Interestingly, the mechanisms involved in epigenetic regulation, such as histone modifications, also participate in the transient changes of gene expression.

This course is therefore opened to all students with an interest in the control of gene expression. There are far-reaching implications of epigenetic research for plant and human biology and disease.

The different mechanisms involved in epigenetic regulation, and the different contexts involving epigenetic regulation will be presented:

- actors involved in epigenetic regulation (role of histone modification, chromatin remodeling complex, histone variants, DNA methylation, small and long noncoding RNA),

- contexts involving an epigenetic regulation (response to cell environment, cell differentiation, development)

Visit the full page about this course

I. LECTURES (20 hours)

1- Cardiac energy metabolism: energetic regulations; cardiac energy transfer

- Bioenergetics and the role of oxygen in bioenergetics

- Contraction in cardiovascular systems, compartmentalization and energy transfer

- Modular organization of cardiac energy metabolism

- Metabolic aspects of the Frank-Starling’s law in the heart

2- Recent progress in basic cardiovascular physiology

- Heart and chronobiology

- Heart rate and longevity

- Cardiac conditioning (pre-conditioning, post-conditioning and remote conditioning)

- Intracellular signaling pathways in vascular systems

- Chronic exercise and vascular function

3- Mechanistic approaches in cardiovascular pathophysiology

- Recent advances in cardiac pharmacology

- Nutrition and cardiovascular risk

- Cardiovascular consequences of obesity and insulin resistance

- Oxidative stress and cardiovascular system

- Strategies for prevention of vascular diseases: pharmacology and prophylaxis

- Endothelial dysfunction in vascular pathologies

4- Vulnerable plaque

- Evolution of the concept of coronary artery disease

-  Vulnerable plaque, a main problem of public health

-  New strategies for vulnerable plaque detection

-  Non-invasive imaging tools: nuclear medicine, ultrafast computed tomography, magnetic resonance imaging

II. TUTORIALS (20 hours

Analysis of scientific publications that illustrate different aspects of the lectures and oral presentations by the students (two to three presentations per student).

Visit the full page about this course

The course is designed to provide students with a broad introduction to cancer biology. Strong emphasis is on cancer genetics (genetic predisposition, gene transcription, DNA repair), epigenetics and functional genomics approaches – including use of genome editing, cell line and animal models and structural biology approaches – and the impact of these in research for deriving new insights into the basic mechanisms and treatment of cancer.

Teaching is interactive and relies on research seminars from experts in the field as well as personal reading and learning (webinars) by the students.

Focus is on developing strong critical analysis skills that can be applied generally to research.

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Course outline

The lectures present the basic methodology and some advanced techniques used for high throughput in vitro small molecule drug discovery. The principles and statistical methods used for assay optimization and validation will also be explained.

I. Molecular biology, Biochemistry and Protein expression

II. Proteomic analysis; Mass spectrometry

III. Lab-chips and Cell-chips

IV. Structural biology: Crystallogenesis and Crystallization; RMN

V. Combinatory chemistry

Format of exams:  Oral exam (at the end of December) and Research project (at the beginning of January)

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Course outline

 At the end of the course, the students should be able to analyze a "omic" dataset. More precisely, they should be able.

1- to load, explore and summarize graphically a dataset.

2- to compute confidence interval estimates for proportions, means and variances.

3- to formulate hypotheses, compute tests statistics, interpret p-values and make practical decisions for the

standard parametric and non-parametric tests.

4- to adjust simple and multiple linear models, analyses of variance (anovas), logistic regression, Cox

model.

5- to select genes that explain a response variable by applying multiple testing approaches.

6- to analyze a data set of differential gene expression.

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Course outline

CM: To provide a comprehensive overview of cancer from basic research to clinical trials: cancer physiopathology; cancer metabolism; proteomics; circadian rhythm and cancer cell characteristics; development of new anti-cancer drugs; imaging in cancer disease.

TD: How to analyze a scientific article critically?

To provide a comprehensive overview of cancer from basic research to clinical trials.

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Full lectures on cognitive, sensory, limbic and motor systems from expert contributors, e.g.:

-       Neural basis of language

-       Brain's rhythms: role and source

-       Neural basis of conscious and non-conscious processes

Full lectures on physiopathology of non-degenerative diseases from MD and PhD contributors, e.g.:

-       Epilepsy physiopathology

-       Schizophrenia physiopathology

-       OCD: new pathophysiological insights

-       Drugs addiction and neuro-adaptation: hijacking of the reward system

Each year, a full day congress will be organized on a particular field, coordinated with other M2 NN modules.

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• Alzheimer
• Parkinson
• Huntington
• Amyotrophic Lateral Sclerosis
• Multiple Sclerosis
• Trauma, Stroke

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The 3h lectures are given by specialists of the field working in Grenoble or in foreign univeristies. They will deal with the following subjects:

• Principle of electrophysiology
• Principle of calcium and voltage membrane potential imaging
• The use of transgenic mice and bi-photon microscopy to monitor the role of glial cells in the brain.
• Ischemia: Glutamate receptors and ischemia
• Of Microtubules and Mitochondria
• Stem cells in the CNS          
• Alzheimer’s disease: from the gene down to the synapse
• Huntington and axonal transport
• Htt links Neurodegeneration to CNS development

10h will be dedicated to presentations of scientific articles by students.

Each year, a full day congress will be organized on a particular field, coordinated with other M2 NN modules.

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Introduction

Science, academic research and entrepreneurship

Innovation

Intellectual properties & juridical forms of companies (in French language due to the specific aspects of the French law)

Marketing of innovation

Customer segmentation

Business development

Project management

Market research

Business plan

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The student will spend 6 months in a research team to work on a scientific project dealing with at least one of the fields covered by the Master 2 PhEDD program.

Finding the research team and the subject relies on the student.

A proposal for this internship should be sent to the module’s coordinator during the spring/early summer of the previous academic year for validation: It must fit to at least one of the fields covered by the Master 2 PhEDDprogram.

The student will be supervised in the lab by a researcher of the field.

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Programme

Vente, client, négociation, prospection, argumentation, conclusion d’une affaire, Programmation Neuro Linguistique, CRM, gestion de la relation client, appel d’offres, vente en ligne, e commerce, écoute active.

Techniques de vente

Phoning et prospection

Communication interpersonnelle

Analyse des prix, marges de négociation, mise en place des tarifications clientèle

Point sur les média sociaux et utilisation dans l’aide à la vente

Le modèle du click and mortar

Etude de cas pour la promotion d’une start-up de la biologie

Gestion de situations de prospection, de suivi d’affaires, de réclamations

Mise en place d’actions commerciales

Réalisation d’argumentaires

Mises en situations commerciales

Evaluation :   moyenne d’épreuves de contrôles continus, d’un examen écrit portant sur les notions étudiées dans le cours, d’un examen oral consistant à présenter les aspects techniques et économiques d’une entreprise.

Intervention : Professionnels et enseignants-chercheurs dans les domaines commerciaux ciblés.

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Marketing

Programme :

• Le comportement du consommateur
• Le marché et les études de marché
• La stratégie et le positionnement
• Le mix : produit, prix, distribution, communication

Objectifs et compétences visées :

• Acquérir les bases théoriques du marketing

• Comprendre la démarche marketing, de l’étude de marché, son analyse, les choix stratégiques et le positionnement et la mise en place du mix.

• Être capable d’analyser une situation de marché et de proposer une stratégie marketing et un marketing opérationnel cohérent.

Gestion comptable, vision  du commerce

Programme :

• Initiation à la gestion comptable et financière
• L’entreprise et ses outils de gestion
• Découverte de l’entreprise et de ses modes de fonctionnement et de décisions
• Les documents de pilotage de l’entreprise 
•  Coût, marge et le seuil de rentabilité 
• Le mécanisme de la TVA
• Analyser et utiliser les données financières

Interventions : Professionnels et enseignants-chercheurs dans les domaines commerciaux ciblés.

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• - Instrumentation : Connaître les instruments les plus courants et leur principe ; comprendre l’organisation d’un appareil ; se servir des données techniques pour argumenter une vente

 Les concepts  techniques d’instruments  sont présentés à travers l’étude de  notices d’appareils commerciaux. Les objectifs sont de fournir les bases scientifiques pour comprendre une notice technique et l’articulation des technologies mises en jeu dans un appareil  et de hiérarchiser les informations en fonction de la demande du client.

Témoignages de professionnels dans les domaines de l’instrumentation et des nanotechnologies.

L’évaluation porte sur un examen de contrôle continu  et un écrit portant sur les notions étudiées dans le cours et TP

• - Nanotechnologie :  Biocapteurs et biopuces : Principes, marchés, conception . Les objectifs sont de donner une vision globale du développement, des applications           et du marché des biocapteurs et des biopuces. 

•  - BioTechnologies :Biotechnologies industrielles. Cellules souches, ingénieries cellulaires ; biotechnologies animales. Vision du marché des biotechnologies     ; TD : Approches scientifiques, technologiques, biomoléculaire dans les domaines des entreprises de biotechnologies. Mise en situations.
• - Etude de cas  n°1 : Analyse des procédés, des produits, des appareillages, technologies, dans les domaines   de la chimie, des biotechnologies, dans le contexte des entreprises

Présentation individuelle, 1H/étudiants devant le groupe.

L’évaluation porte sur la présentation écrite et orale  de  projets d’exposés personnels et de contrôle continu  sur des thématiques choisis.

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• - Immunotechnologie : Présentation des bases en immunologie dans le but de comprendre  les applications technologiques des outils » dérivés de l’immunologie.  Etude des enjeux socio-écomomiques du marché de l’immunotechnologie. Quelques applicationsissus de l’immunologie : instruments outils  et technologies: - la cytométrie en flux (CMF) ; Les anticorps et les immunoessais ; l’immunomonitoring ;  les biomédicaments : les anticorps monoclonaux  thérapeutiques.
• Projet  tutoré : par binôme d’étudiant : Analyse d’une thématique d’immunologie en lien avec les domaines scientifiques appliqués de l’immunologie, la santé et les enjeux  économiques des entreprises des secteurs ciblés.

L’évaluation porte sur la moyenne d’épreuves de contrôle continu, d’un mémoire thématique, et de  l’oral de  sa présentation.

• Témoignages de professionnel  d’entreprises dans le domaine de l’immunologie : illustration de la Connaissances des produits et des entreprises du secteur

• Bioproduction : Descriptif des différents systèmes de production des protéines recombinantes, les méthodes de production des médicaments biologiques à l’échelle du laboratoire et au niveau industriel ; introduction sur le marché mondial des biomédicaments et de leurs applications thérapeutiques (illustrées par des exemples). -

• -  Assurances qualité et métrologie : Généralités, accréditation COFRAC - Métrologie 

Intervenants : Professionnels

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• Droit commercial : Droit appliqué à la négociation commerciale : négocier la conclusion de contrats préparés par le service juridique et gérer la relation avec le client lors de l’exécution du contrat ; Initiation aux appels d’offres

Programme :

• La connaissance l’environnement juridique
• Le contentieux
• La conclusion et l’exécution  d’un marché
• Les parties contractantes

• Outils des systèmes d’informations et leur utilisation pour et dans le métier de Commercial

Programme

• Connaissance de l’organisation d’entreprise : présentation des organisations et outils  de la CRM/GRC et utilisation. Pratique opérationnelle et stratégique de différents outils ou supports Préparation à l’embauche, parcours professionnels, CV, entretien

• Anglais commercial : mise en situation de négociation en anglais pour l’international

Programme :

Living, working and negotiating in a multicultural environment

 -  Identifying cultures with their differences and similarities 

 -  Introduction to a new international culture (without denying the specific cultures).

• Communication scientifique : Pratique et mise en situation de la communication adaptée aux interlocuteurs dans l’entreprise

Programme :

• Une introduction rapide à la communication : une initiation à la démarche communicationnelle 
• Analyse critique des supports de communication pour la vente (appareillage, produit, service) en bio-med-techs dont une partie sélectionnée par des étudiants
• Analyse critique et constructive d interventions orales
• Préparation à la communication écrite du MPA et sa soutenance
• Ecrire un résumé du MPA bref, informatif et agréable efficace !

Interventions : Professionnels dans les domaines commerciaux ciblés.

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Activité professionnelle en alternance en entreprise (3 semaines/mois sur une année) : en apprentissage au fil de l’année en entreprise

• Méthodologie : Aide (méthodes, consignes, outils) et suivi individuel à la réalisation du mémoire professionnel d’apprentissage ( MPA) ; Travail personnel à la réalisation; Suivi individualisé et tutoré.

Programme :

• Exposé des attentes et objectifs
• Travail et choix de la problématique de MPA, à la jonction des attentes scientifiques et commerciales
• Prise en compte de l’entreprise, de ses attentes et de la tâche
• Construction d’un plan détaillé avec aspects théoriques et méthodologiques
• Travail des aspects formels et rédactionnels
• Préparation de l’oral de soutenance

Objectifs et compétences visés :

• Construire avec une méthodologie rigoureuse son mémoire de Master- 2
• Communiquer efficacement, d’un point de vue formel et universitaire,  à l’écrit comme à l’oral
• Envisager deux aspects spécifiques du « mémoire d’apprentissage » : rapport de stage et mémoire
• Apprendre à évaluer la production d’un collègue et auto-évaluer sa propre production

Evaluation : contrôles continus validés  par l’enseignant et  les tuteurs.

• suivi précis du travail demandé et des étapes dans la réalisation de l’écriture du mémoire professionnel - au cours des 4 séances de TD 
• assiduité, qualité des interactions et motivation de l’étudiant en cours
• capacité à évaluer et s’auto-évaluer
• suivi et communication réalisés conjointement avec la responsable du Master

L’évaluation finale du »Stage » : réalisation d’un mémoire écrit professionnel d’apprentissage (MPA), comprenant  la  réponse à une problématique d’entreprise ;  soutenance orale 

Intervenants : Maîtres d’apprentissage en entreprise ; Tuteurs académiques (des domaines  scientifiques et commerciaux ; Professionnels 

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Choix d'un ETC si niveau anglais >= B2

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Communication and Sales Technics: Payment conditions, letters of credit

Incoterms, tenders, Management of a distribution networks :(agent, distributor, reseller, internet):

Introductions to commercial situations

E-commerce and international customer approach, internet

Strategies to sell technical and scientific products. B to B specifications (B to B: Business to Business).

Targets and goals,

Communication skills: NLP: Neuro linguistic Programmation: Purchasing and offer of tenders.

Commercial practices in foreign countries

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How to approach a foreign market

Decision between a distributor, agent and direct access to the market

Health or Politicial policies in the world,

How to offer products to clients and differences between the countries.

Different processes of purchase behaviors all around the world in the scientific and industrial field and countries.

Marketing mix; E-marketing; Specific means of communication; Distribution channel policy; Advertising and communication

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Focus on the cultural approach in business to succeed and find distributors or agents to increase the business

Importance of mediation in business.

International trade law and regulatory requirements. European law

From history to customer behaviors; Trends and habits of the markets. 

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Accounting, costs and margins

Strategy and quality management

Purchasing; Production.

The aim of the training is to understand concepts such as margin, costs, turn-over, results, commercial information system.

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The course aims to present up to date technologies used in Biotech Companies for genetic engineering, bioprocessing, molecular diagnostic, high-throughput screening, immunotechnology, stem cell and tissue engineering, animal technologies and industrial biotechnology. An analytical assessment is required from students in regard of technology/science and economics criteria.

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The course aims at explaining the basic principles of the technologies used for imaging at the nano-, micro- and macroscopic scales in life sciences, and at presenting several applications of these technologies for imaging molecules, cells and tissues, for in vivo imaging in small animals, and for investigating the dynamics and interactions of biomolecules. The course will include several visits of imaging platforms in the Grenoble area.

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Preparation of a commercial CV and presentation.

Discovery of commercial and international jobs with professional people.

Meeting with companies which offer internships and presentation of their products.

Participation in exhibitions of the field

Table discussions with companies located in Archamps (Biopole).

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Students are in charge of a commercial project. During all the practical period, students analyze, study, suggest solutions to solve a commercial problem.

This practical part is a team project: the goal is to get training in working together for a common goal to achieve. This includes an assessment of the team self-organization by the team itself.

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Visit the full page about this course

Visit the full page about this course

During the internship, a commercial mission will be organized by the student for a French or a foreign company. The target will be to develop a new market for a company, to increase sales on an existing market with scientific products from biology or chemistry.

Visit the full page about this course

Visit the full page about this course

Visit the full page about this course

Visit the full page about this course

Visit the full page about this course

Visit the full page about this course

Visit the full page about this course

Visit the full page about this course

Visit the full page about this course

Visit the full page about this course

Visit the full page about this course

Visit the full page about this course

Visit the full page about this course