UE Integrative structural cell biology

Degrees incorporating this pedagocial element :


The course aims at introducing the students to advance and modern methods in structural biology that integrate structural and/or dynamical information at different levels of resolution.  

- Structure of large biomolecular assemblies

  •  Obtaining key information on large biomolecular assemblies and systems
  •  Electron microscopy and tomography
  •  NMR spectroscopy
  • X-ray and neutron diffraction
  • Hybrid approaches (combination of high- and low-resolution structural methods)
  •  Structure of ribosome, signal recognition particle, viruses,…

- From macromolecules to the cell

  •  High resolution optical microscopy
  •  Atomic force microscopy
  •  Correlative electron microscopy (combination of optical and electron microscopy)
  •  Structure and dynamics of the cytoskeleton
  •  Biology of flower …..

- Dynamics of biomolecular systems

  •  Dynamics by NMR spectroscopy
  •  Neutron spectroscopy
  •  Molecular dynamic simulations
  • Intrinsically disordered proteins

Targeted skills


Understanding concepts, prospects and current problems of integrative structural biology, integrating results from different methods (EM, high-resolution optical microscopy, X-ray, NMR, SAXS/SANS, molecular dynamics simulation and functional data), expertise in electron microscopy reconstruction and in hybrid structural methods, insight into large macromolecular assemblies and macromolecular dynamics.