UE Chemistry and Biochemistry

Course outline

• Biocatalysis

         Basis in Enzymes cofactors and vitamins

         Cofactors involved in group transfer

         Cofactors involved in redox reaction

         Cofactors and chemical origin of life

• Biological Chemistry of Oxygen

          Chemistry of O₂

          Defense mechanism, detoxification of reactive oxygen species (ROS)

          Role of ROS in physio-pathology

          Regulation, sensing mechanism

          Cellular sources of ROS.

•  Membrane Biochemistry

         Lipids, Membrane and Rafts

         Membrane proteins: synthesis and topology

         Membrane proteins and detergent biochemistry

         Receptors

         Transporters

         Vesicular trafficking.

•   Biochemistry of viral infection and immunity

         Membrane fusion

         Membrane budding

         Biochemistry of innate factors

•   Extracellular Biochemistry: GAGs

         Extracellulaire matrices

         Glycosaminoglycans (GAG): biosynthesis and catabolism

         GAG: biological activities

         GAG: pathology and applications

•   Methods of study

         Molecualr factory characterisation : cryoelectron microscopy

         Imaging complexes, location and dynamic in cellulo

This module brings strong background (relative to oxidative stress) to the Unit “Experimental Approaches in Biology”