UE Synaptic Plasticity of the adult nervous system

Degrees incorporating this pedagocial element :


The 3h lectures are given by specialists of the field working in Grenoble or in foreign univeristies. They will deal with the following subjects:

  • Principle of electrophysiology
  • Principle of calcium and voltage membrane potential imaging
  • The use of transgenic mice and bi-photon microscopy to monitor the role of glial cells in the brain.
  • Ischemia: Glutamate receptors and ischemia
  • Of Microtubules and Mitochondria
  • Stem cells in the CNS          
  • Alzheimer’s disease: from the gene down to the synapse
  • Huntington and axonal transport
  • Htt links Neurodegeneration to CNS development


10h will be dedicated to presentations of scientific articles by students.


Each year, a full day congress will be organized on a particular field, coordinated with other M2 NN modules.

Targeted skills

After this module, the students should be able to:

  1. Recapitulate the basic cellular and molecular mechanisms underlying learning and memory as well as those compromised in neurodegenerative diseases.
  2. Apprehend the state-of-the art methods allowing studies of synaptic plasticity both in vitro and in vivo.
  3. Explain experimental strategies used in a scientific study, analyze and discuss the results.