Master in Chemistry

The purpose of this course is to further teach experimental chemsitry to the student  by working on synthetic projects during which they will reinforce their experimental knowledge. The students will first have to find, via  bibliographic research, the experimetnal procedure they will then set up and conduce during a full week of work in the laboratory.

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The goal of this course is to give chemists a solid theoretical (through lectures) and practical (through tutorials) background and know how in chemical analysis. Building on previous introductory undergraduate classes, the course will study more specifically the diverse purification and separation chromatographic technics, and the methods used to characterize chemical samples by mass spectrometry, atomic absorption, optical spectroscopies (infrared, Raman, UV-visible, fluorescence, X-ray diffraction) and magnetic spectroscopies (NMR and EPR). The spectroscopic approaches will be developed for structural studies of isolated molecules in solution or in the solid state. Techniques used to characterize intermolecular interaction and molecular reactivity of organic, inorganic or polymer materials will also be investigated.

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During this  course  a non-exhaustive way the various classes of protective group as well as their selective deprotection will be presented. Their use in chemistry of sugars, peptides and in total synthesis will be particularly exposed. The main reactions of oxidation, reduction and olefination will then be detailed through their mechanisms and selectivities.

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The purpose of this course is to teach students reaction involving organometallic species. It will include electronic   structures of complexes, elementary organometallic reactions and then their use in synthesis  (organo-lithium, -magnesium , -zinc, -copper/ hydrogenations/ cross coupling/metal-carbenes complexes/metal polyenes/  C-H activation).

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This course gives an overview of the polymer field from the synthesis of polymers to characterization, properties, and applications of synthetic and natural polymers. All major polymerization methods, their reaction mechanisms and kinetic aspects are considered: step growth polymerization, chain growth polymerization with ionic and radical variations, insertion polymerization. A lecture portion is integrated with a laboratory component, in which experiments are conducted that are directly connected to the class work. Analysis of  polymer solution properties and caracterization techniques are presented :  thermodynamics, polymer/solvent interactions, average molecular weight determination via osmometry, ligth scattering, viscosimetry and SEC.

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This course focuses on the chemistry, i.e. synthesis and reactivity, of peptides and saccharides. The basics of their synthesis will be first reviewed. Specific interactions of metal ions with those biomolecules will be then discussed as they play very important role in their structuration and function and thus in health and medicine.

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The Master 1 internship is a key moment in the evolution and orientation of the student during the master. Placed at the end of the year, in an academic laboratory or in a company, this internship will last at least 8 weeks in France, and up to 12 weeks for an internship abroad.

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This course is divided in four main parts. The first part focusses on physical chemistry , necessary for a good understanding of chemical transformation. In the second part the chemistry of enolates will be detailed through the study of major reactions: alkylation, aldol, Claisen and 1-4 addition reactions. In the third part, pericyclic reactions will be studied (electrocyclic, cycloaddition and sigmatropic reactions). Finally the chemistry of free radicals and carbenes will be introduced. The course includes formal lectures and tutorial classes.

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This teaching block is divided into two sections, bioinorganic chemistry and bioorganic chemistry. Bioorganic chemistry part is focused on the heterocycles chemistry mainly nitrogen(s) containing compounds (i.e. pyridines, pyrimidines, pyrroles, purines and nucleosides). Indeed heterocyclic compounds represent interesting organic compounds as they are involved in the design of many pharmaceutics as well as in biological processes. An overview of the roles that are played by the metal ions in life (biotransformations, dioxygen transport, drug elimination) and specially in the stabilization of nucleic acids will then be presented.

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This course gives an overview of the polymer field from the synthesis of polymers to characterization, properties, and applications of synthetic and natural polymers. All major polymerization methods, their reaction mechanisms and kinetic aspects are considered: step growth polymerization, chain growth polymerization with ionic and radical variations, insertion polymerization. A lecture portion is integrated with a laboratory component, in which experiments are conducted that are directly connected to the class work. Analysis of  polymer solution properties and caracterization techniques are presented :  thermodynamics, polymer/solvent interactions, average molecular weight determination via osmometry, ligth scattering, viscosimetry and SEC.

This course is divided in two parts covering selected aspects of polymer chemistry and physical chemistry. The chemistry part aims to help students better understand contemporary polymer science focusing on syntheses and materials properties of polymers. It covers copolymer synthesis, discussing control of copolymer composition and relevant recent research such as controlled radical polymerization, supramolecular polymers and bio-based polymers. The course will also provide detailed information for polymerization techniques and polymer characterization tools.

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The course will present the experimental strategies used to produce macromolecular samples for biophysical, structural studies and biotechnical applications, from bioinformatics analysis to recombinant protein expression systems, automation (robotics), purification and engineering and measurement of sample quality. Expected competences acquired by the students: expertise in bioinformatic analysis of macromolecule sequence and structure, understanding methods and strategies used to express and purify macromolecules, expertise in experimental methods used for sample quality control, practical experience on platforms on the EPN Campus.

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The lab project "organic syntheses" or  “Polymer” or "Chemistry of Life Science" is a one-week immersion into the world of research labs. Students will have to focus on specific objectives: total synthesis, synthesis of ligands, synthesis of polymer, asymmetric catalysis … They will have to carry out bibliography searching, compare the available methods, plan the synthesis (reactants and solvents needed) as well as establishing a suitable retrosynthesis. An important part of characterization of the products will be realised, in particular in the lab project “Polymer”.

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The English class in M1 chemistry aims at enabling students to find relevant information and main points in academic written texts quickly, to communicate on the basis of research articles in chemistry and to prepare and present scientific posters in their fields of studies.

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Dans ce cours seront présentées les techniques de chromatographie, avec des rappels théoriques et des généralités sur les différents principes et appareillage. Une seconde partie concernera les techniques de spectroscopie où seront abordés les bases théoriques et le principe de fonctionnement des appareils.

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Des généralités sur les systèmes de préparation, statistiques et incertitudes. Méthodes classiques et impulsionnelles en électrochimie. Analyses environnementales DBO et DCO.

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Programme

Vente, client, négociation, prospection, argumentation, conclusion d’une affaire, Programmation Neuro Linguistique, CRM, gestion de la relation client, appel d’offres, vente en ligne, e commerce, écoute active.

Techniques de vente

Phoning et prospection

Communication interpersonnelle

Analyse des prix, marges de négociation, mise en place des tarifications clientèle

Point sur les média sociaux et utilisation dans l’aide à la vente

Le modèle du click and mortar

Etude de cas pour la promotion d’une start-up de la biologie

Gestion de situations de prospection, de suivi d’affaires, de réclamations

Mise en place d’actions commerciales

Réalisation d’argumentaires

Mises en situations commerciales

Evaluation :   moyenne d’épreuves de contrôles continus, d’un examen écrit portant sur les notions étudiées dans le cours, d’un examen oral consistant à présenter les aspects techniques et économiques d’une entreprise.

Intervention : Professionnels et enseignants-chercheurs dans les domaines commerciaux ciblés.

Objectifs et compétences visées :

Cet enseignement met le client au cœur de la formation,  en apprenant à dialoguer avec lui, à le prospecter, le fidéliser et construire avec lui une solution technique et commerciale à ses besoins.  La compétence développée est de savoir vendre des produits techniques accompagnés de services, de produits complémentaires et d’offres évolutives dans le temps chez le client et surtout de bien appréhender la situation d’achat du client. Apprentissage de la négociation commerciale. E.commerce (opportunités, limites et organisation).

Savoir créer, gérer et suivre une relation commerciale avec ses clients. Capacité à réaliser du commerce avec détermination mais beaucoup de souplesse. Apprendre à parler au client en s’adaptant aux situations proposées diverses et individualisées. Savoir adapter une stratégie de vente à la stratégie d’achat du client. Importance du savoir-être comme acquisition des compétences commerciales. Savoir fidéliser et suivre l’évolution des affaires de ses clients. Prospection de la clientèle jusqu’à la concrétisation d’une affaire. Savoir gérer les outils du commerce digital et les médias sociaux.

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Marketing

Programme :

• Le comportement du consommateur
• Le marché et les études de marché
• La stratégie et le positionnement
• Le mix : produit, prix, distribution, communication

Objectifs et compétences visées :

• Acquérir les bases théoriques du marketing

• Comprendre la démarche marketing, de l’étude de marché, son analyse, les choix stratégiques et le positionnement et la mise en place du mix.

• Être capable d’analyser une situation de marché et de proposer une stratégie marketing et un marketing opérationnel cohérent.

Gestion comptable, vision  du commerce

Programme :

• Initiation à la gestion comptable et financière
• L’entreprise et ses outils de gestion
• Découverte de l’entreprise et de ses modes de fonctionnement et de décisions
• Les documents de pilotage de l’entreprise 
•  Coût, marge et le seuil de rentabilité 
• Le mécanisme de la TVA
• Analyser et utiliser les données financières

Interventions : Professionnels et enseignants-chercheurs dans les domaines commerciaux ciblés.

Objectifs et compétences visées

• Permettre de dialoguer efficacement avec des directeurs financiers, comprendre l’incidence des décisions commerciales sur les résultats de l’entreprise, décrypter l’information financière disponible sur les entreprises, enrichir les connaissances sur les rouages d’une entreprise et préciser le vocabulaire économique.
• Se préparer au développement du Business Plan d’une entreprise.

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• Droit commercial : Droit appliqué à la négociation commerciale : négocier la conclusion de contrats préparés par le service juridique et gérer la relation avec le client lors de l’exécution du contrat ; Initiation aux appels d’offres

Programme :

• La connaissance l’environnement juridique
• Le contentieux
• La conclusion et l’exécution  d’un marché
• Les parties contractantes

• Outils des systèmes d’informations et leur utilisation pour et dans le métier de Commercial

Programme

• Connaissance de l’organisation d’entreprise : présentation des organisations et outils  de la CRM/GRC et utilisation. Pratique opérationnelle et stratégique de différents outils ou supports Préparation à l’embauche, parcours professionnels, CV, entretien

• Anglais commercial : mise en situation de négociation en anglais pour l’international

Programme :

Living, working and negotiating in a multicultural environment

 -  Identifying cultures with their differences and similarities 

 -  Introduction to a new international culture (without denying the specific cultures).

• Communication scientifique : Pratique et mise en situation de la communication adaptée aux interlocuteurs dans l’entreprise

Programme :

• Une introduction rapide à la communication : une initiation à la démarche communicationnelle 
• Analyse critique des supports de communication pour la vente (appareillage, produit, service) en bio-med-techs dont une partie sélectionnée par des étudiants
• Analyse critique et constructive d interventions orales
• Préparation à la communication écrite du MPA et sa soutenance
• Ecrire un résumé du MPA bref, informatif et agréable efficace !

Interventions : Professionnels dans les domaines commerciaux ciblés.

Objectifs et compétences visées

- Sensibiliser aux approches de communication

- S'exercer à adapter la teneur scientifique du message à la situation communicationnelle, l’appauvrir ou l'enrichir selon les besoins.

- Communiquer efficacement à l'écrit et à l'oral... d'un point de vue journalistique.

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L'objet du stage en alternance est de mettre en pratique l'ensemble des connaissances théoriques et pratiques acquises par l'étudiant notamment dans le domaine commercial, tout en faisant appel à ses solides connaissances scientifiques. Une mission clairement identifiée sera confiée au stagiaire, qui sera en charge de son accomplissement et de la présentation des méthodes mises en oeuvres et des résultats obtenus dans un rapport professionnel d'apprentissage et via une présentation orale. Des consignes précises seront données pour la réalisation du plan et l'élaboration de contenu du rapport d'apprentissage.

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The syllabus of the English course in M2 aims at enabling students to validate 3 competences that will be essential for their working life or for their doctoral studies in the future, at the B2 level: 1°) CAN give a clear presentation on a familiar topic, and CAN answer predictable or factual questions 2°) CAN find relevant information and essential points in written texts 3°) CAN make simple notes that are of reasonable use for essay or revision purposes, capturing most important points." (CEF, appendix D). Reading comprehension can be validated in M1. The course contents are linked to the students' fields of studies.

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Course outline:

This course describes synthetic approaches and methods for: the synthesis of library of small[1]molecules, the assembly of peptide and analogs, the engineering of molecular conjugates of biomolecules, and the applications of that family of molecules in therapeutics, diagnostics and nanotechnologies (i.e. biosensors).

Details:

1/ Peptides and protein engineering

I.Structural aspects

II.Synthetic strategies (SPPS, fragment synthesis, native ligation)

III.Applications in vectorization (Monoclonal antibodies, cell-penetrating peptides, peptide ligands, nanoparticles)

IV.Antimicrobial peptides, toxins

V.Pseudopeptides

2/ Chemical ligation

I. The different reactions

II.Multiple chemoselective ligations

III.Installing bioorthogonal functionality into target biomolecules

IV.In vivo click chemistry

3/ Combinatorial chemistry

I. Drug Discovery

II.Synthetic strategies (combinatorial vs parallel synthesis; solid vs supported synthesis)

III.Dynamic Combinatorial Chemistry / Target guided synthesis

4/ Biosensors

I. Medicinal, environment and food safety applications

II.Biomolecules for molecular recognition

III.Chemical modifications for immobilization and transduction

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This teaching module focuses on the main principles used in bioinorganic chemistry: i) to understand and mimic the metal binding sites naturally found in biological systems, and ii) to anticipate potential interactions of toxic metals or metal-based drugs in living organisms. A first part will be dedicated to the behavior of metal complexes in biologically-relevant conditions. We will present the main analytical and spectroscopic tools useful to decipher the nature of the metal complexes both in abiotic compounds and proteins. In a second part, important metal active sites (on the catalytic, therapeutic and biological points of view) will be described in details. The last part deals with the concept of bioinspired chemistry. We will see how bioinorganic chemists design complexes that are able to mimic natural systems.

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This course will (i) provide advanced knowledge on biological therapeutic targets to facilitate understanding of projects at chemistry-biology interface, (ii) introduce current and innovative projects bringing together chemists and biologists, and (iii) give methodologies to effectively synthesize scientific oral presentation and publication.

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Green chemsitry is a major evolution in organic chemistry for more efficient, sustainable transformations while minimizing by-products, solvents and waste. In this course, the 12 principle of green chemistry will be presented and illustrated through dedicated chapters to: solvents, catalysis, biotransformation, flow chemistry, organocatalysis and multicomponent and cascade reactions.

Details:

I – Introduction: History, E-factor, 12 principles
II- Solvents: greener solvent, no solvent, water, supercritical CO2, Ionic liquids,
III- Biocatalysis – Biomass
IV- Solids supported reaction/reagents, flow chemistry
V- Microwaves
VI- Multicomponent and cascade reactions
VII- Organocatalysis

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Cette unité d’enseignement de 3 ECTS est enseignée en Français et est divisée en trois grandes parties : Gestion de projet, Propriété industrielle, Plans d’expérience.

Gestion de projet

Le cours se compose de deux parties :

1. Communication qui est la poursuite de l’UE Communication tools pour approfondir la connaissance de soi et savoir se présenter lors d’un entretien de recrutement

2. Gestion de projet: Initiation à la gestion entrepreneurial permettant d’avoir un aperçu des outils de gestion de projets, des bases en gestion
et en entrepreneuriat.

Propriété industrielle

Résumé du cours : principes fondamentaux des droits de propriété intellectuelle : conditions, effets et exceptions des droits de brevet, savoir-faire, marque, dessin et modèle, obtentions végétales, topographie des semi-conducteurs, de la contrefaçon.

Détails :
Droit du brevet : conditions de fond, de forme pour obtention du titre. Effets et limites du brevet, national et européen.
Droit de la marque : conditions de fond, de forme pour obtention du titre. Effets et limites de la marque, nationale et européenne.
Droit des dessins et modèles: conditions de fond, de forme pour obtention du titre. Effets et limites du titre, national et européen.
Principes des topographies de semi-conducteur, obtention végétales, droit d’auteur.
L’action en contrefaçon : la preuve, les démarches, les résultats.

Plans d’expériences

Résumé du cours : Le cours traite des principaux plans d’expériences habituellement rencontrés (plan factoriels complet, plan factoriels fractionnaire, plans pour surface de réponses). L’analyse statistique des plans d’expériences sera également abordée.

Détails : Le cours est constitué des 4 items suivant :

• Les plans factoriels complets
• Les plans factoriels fractionnaires
• Plan pour surface de réponses
• Traitement statistique des plans d’expériences

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Cette UE est enseignée en Français.

Introduction au management de l’Hygiène, la Sécurité, l’Environnement au travail : aspects réglementaires (code du travail et code de l’environnement), principes d’évaluation des risques, Installations Classées pour la Protection de l’Environnement, prévention des risques au travail et environnementaux : en particulier en ce qui concerne le risque incendie, le risque électrique et les risques chimiques (étiquetage, FDS, dangers, équipements de protection, transport de matière dangereuse, etc…).

Détails:

1. Prévention des risques professionnels
2. Prévention des risques environnementaux
3. Les risques chimiques
4. Le risque incendie
5. Le risque électrique

Connaissance :
- des obligations en sécurité au travail (employeur et salariés),
- de techniques de prévention des risques,
- d’impacts environnementaux liés aux activités industrielles.

Gestion comptable:

Organisation du cours :

Les séances seront articulées autour d’une simulation de gestion pour aborder progressivement et empiriquement les notions suivantes :

1. Le Bilan
2. Le compte de résultat et la trésorerie
3. Les coûts de revient et les marges
4. Les seuils de rentabilité

Objectifs :
- S’approprier le vocabulaire de la comptabilité
- Savoir lire les documents comptables : bilan, compte de résultat
- Savoir analyser les principaux résultats financiers : rentabilité, solvabilité.
- Savoir calculer un coût de revient simple
- Savoir déterminer un seuil de rentabilité.

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It is recognized that a large number of bioactive compounds are cyclic molecules containing one or several heteroatoms (N, O, S, etc…). In this course, the chemical properties of the most representative 6- and 5-membered-ring  types of heterocycles and the major methods used for their synthesis will be reviewed. Applications will be extended to more complex structures. Nomenclature rules will also be explained and exemplified.

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Course outline:

The main part of the course deals with the chemical development of an active ingredient (i.e. pharmaceutical ingredient or agrochemical) from milligrams to tons: how the discovery chemistry synthesis route evolves into a manufacturing process. Besides, several lessons aim to revive prior knowledge of industrial
organic chemistry, with emphasis on the connections between raw materials, commodity chemicals and applications.

Details:

- The chemical development of a bioactive compound is first addressed through an open discussion. Students then work individually and in small teams to gather informations from selected publications. Their reports to the class allow all students to discover important aspects of chemical development. The topic is later on presented extensively by professionals from the industry (lectures). Tutorials dealing especially with the safety of chemical processes complete the course.

- After a brief overview of the business sectors related to chemistry and the sources of organic chemicals (petroleum, coal, biomass), selected end products are traced back to the commodity chemical they are synthesized from, and further to the raw materials (quiz and lectures).

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Details:

A. Molécules bioactives et médicaments : modes d’action et conceptions (5 cours, Benjamin Boucherle, UFR de Pharmacie)

Le médicament (1 cours) :
Définition et généralités ; Processus de recherche et développement des médicaments ; De la cible au candidat médicament préclinique ; Les essais cliniques ; Aspects règlementaires (AMM) ;
Petites molécules chimiques vs biomolécules

Introduction à la pharmacologie (3 cours)
Rappel de physiologie : Procaryote et eucaryote ; De la cellule à l’organisme
Pharmacologie : Définitions et concepts ; Ligand – cibles ; Agonistes et antagonistes ; Devenir in vivo des médicaments

Conception de médicament (1 cours)
Différents types de conception (basée sur le récepteur, basée sur le ligand, méthodes des fragments) ; Relation Structure-Activité ; Modélisation moléculaire (QSAR et amarrage moléculaire) ; Evaluations biochimiques des molécules bioactives

B. Exemple de grandes classe de médicaments
Objectifs : savoir reconnaitre les structures chimiques des molécules chefs de file étudiées, et reconnaitre les cibles biologiques des molécules chefs de file, connaitre le mécanisme d’action des molécules chefs de file.
Maitriser les approches de conception qui ont permis la mise au point de médicaments à partir de molécules chefs de file. Connaitre les éléments de bases liés à l’incidence de la métabolisation sur l’activité des molécules étudiées.
- Analgésiques (morphiniques et non morphiniques), Anesthésiques locaux, Anti-inflammatoires
- Médicaments du système nerveux central

C. Agents chimiothérapeutiques
Objectifs : à l'issue de ce cours, l'étudiant devra avoir une connaissance des éléments essentiels de la structure des principaux (ou principales familles de) principes actifs ainsi que de leur(s) cible(s) et leur(s) mécanisme(s) d'action(s).
- Anticancéreux : différentes approches, mécanismes d’action (agents alkylants, intercalants, nucléosides précurseurs d’inhibiteurs de la synthèse et de la modification de l’ADN, antimitotiques, etc....)
- Antiviraux : inhibiteurs de polymérases, de protéases…
- Antibiotiques :  sulfamides antibactériens, inhibiteurs de la synthèse des protéines, médicaments contre la tuberculose
- Antipaludéens

Objectifs :

à l'issue de ce cours, l'étudiant devra avoir une connaissance des éléments essentiels de la structure des principaux (ou principales familles de) principes actifs ainsi que de leur(s) cible(s) et leur(s) mécanisme(s) d'action(s).
- Anticancéreux : différentes approches, mécanismes d’action (agents alkylants, intercalants, nucléosides précurseurs d’inhibiteurs de la synthèse et de la modification de l’ADN, antimitotiques, etc....)
- Antiviraux : inhibiteurs de polymérases, de protéases…
- Antibiotiques :  sulfamides antibactériens, inhibiteurs de la synthèse des protéines, médicaments contre la tuberculose
- Antipaludéens

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Course outline:

This course describes synthetic approaches and methods for: the synthesis of library of small[1]molecules, the assembly of peptide and analogs, the engineering of molecular conjugates of biomolecules, and the applications of that family of molecules in therapeutics, diagnostics and nanotechnologies (i.e. biosensors).

Details:

1/ Peptides and protein engineering

I.Structural aspects

II.Synthetic strategies (SPPS, fragment synthesis, native ligation)

III.Applications in vectorization (Monoclonal antibodies, cell-penetrating peptides, peptide ligands, nanoparticles)

IV.Antimicrobial peptides, toxins

V.Pseudopeptides

2/ Chemical ligation

I. The different reactions

II.Multiple chemoselective ligations

III.Installing bioorthogonal functionality into target biomolecules

IV.In vivo click chemistry

3/ Combinatorial chemistry

I. Drug Discovery

II.Synthetic strategies (combinatorial vs parallel synthesis; solid vs supported synthesis)

III.Dynamic Combinatorial Chemistry / Target guided synthesis

4/ Biosensors

I. Medicinal, environment and food safety applications

II.Biomolecules for molecular recognition

III.Chemical modifications for immobilization and transduction

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This teaching module focuses on the main principles used in bioinorganic chemistry: i) to understand and mimic the metal binding sites naturally found in biological systems, and ii) to anticipate potential interactions of toxic metals or metal-based drugs in living organisms. A first part will be dedicated to the behavior of metal complexes in biologically-relevant conditions. We will present the main analytical and spectroscopic tools useful to decipher the nature of the metal complexes both in abiotic compounds and proteins. In a second part, important metal active sites (on the catalytic, therapeutic and biological points of view) will be described in details. The last part deals with the concept of bioinspired chemistry. We will see how bioinorganic chemists design complexes that are able to mimic natural systems.

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This course will (i) provide advanced knowledge on biological therapeutic targets to facilitate understanding of projects at chemistry-biology interface, (ii) introduce current and innovative projects bringing together chemists and biologists, and (iii) give methodologies to effectively synthesize scientific oral presentation and publication.

Visit the full page about this course

Visit the full page about this course

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Course outline

The lectures present the basic methodology and some advanced techniques used for high throughput in vitro small molecule drug discovery. The principles and statistical methods used for assay optimization and validation will also be explained.

I. Molecular biology, Biochemistry and Protein expression

II. Proteomic analysis; Mass spectrometry

III. Lab-chips and Cell-chips

IV. Structural biology: Crystallogenesis and Crystallization; RMN

V. Combinatory chemistry

Format of exams:  Oral exam (at the end of December) and Research project (at the beginning of January)

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The course will present practical and theoretical aspects of the classical approaches used to determine the structure of macromolecules by X-ray crystallography and Nuclear Magnetic Resonance spectroscopy. The program of this course is described below:

  Part I - Crystallography - 20h

• Crystallization techniques                                                                            
• Crystal symmetry and space groups                                                                      
• Diffraction                                                                                                    
• Structure factors, reciprocal space etc                                                      
• Tutorial: Data treatment                                                                                          
• Phasing – MIR, SAD, MAD                                                                        
• Molecular replacement, crystallographic symmetry                                              
• Tutorial: MAD Phasing                                                                                              
• Tutorial: Molecular replacement                                                                             
• Refinement                                                                                                  
• Tutorial: Model building and refinement                                                                  
• Practical lab: Crystallization on a PSB platform                                                                 
• Practical lab: X-ray data collection on a ESRF beamline                                                  

    Part II – Nuclear Magnetic Resonance-20h

• NMR principles: active nuclei, magnetic field, radiofrequency excitation,
             return to equilibrium                                                                                     
• NMR observables in the spectra of biomolecules (chem. shift, scalar
             couplings,  linewidth)                                                                        
• NMR observables: measurement                                                               
• Practical lab on IBS-NMR platform: data collection
• The steps to structure determination: sample preparation, isotopic labeling
• The steps to structure determination: assignment   
• The steps to structure determination: extraction of structural parameters 
• Tutorial: Data analysis                                                                                 
• Structure calculation: principles                                                                              
• Practical lab: Protein structure calculation  

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It is recognized that a large number of bioactive compounds are cyclic molecules containing one or several heteroatoms (N, O, S, etc…). In this course, the chemical properties of the most representative 6- and 5-membered-ring  types of heterocycles and the major methods used for their synthesis will be reviewed. Applications will be extended to more complex structures. Nomenclature rules will also be explained and exemplified.

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Course outline:

Common modelling methods based on classical (MM, MD) and quantal (HF, DFT) approaches are addressed and their application are illustrated during lectures. Three computational labs are made to make students familiar with the application of these methods.

Details:

I. Lect1- Introduction: The potential energy surface
II. Lect2- Molecular Mechanics, Forcefield methods
III. Lab1- Forcefield methods, exploration of a potential energy surface
IV. Lect3- Ab initio methods, the self-consistent field, basis sets, density functional theory and applications
V. Lab2- ab initio methods: electron structure, reactivity
VI. Lect4- Molecular Dynamics simulations
VII. Lab3- Molecular Dynamics Simulations

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Green chemsitry is a major evolution in organic chemistry for more efficient, sustainable transformations while minimizing by-products, solvents and waste. In this course, the 12 principle of green chemistry will be presented and illustrated through dedicated chapters to: solvents, catalysis, biotransformation, flow chemistry, organocatalysis and multicomponent and cascade reactions.

Details:

I – Introduction: History, E-factor, 12 principles
II- Solvents: greener solvent, no solvent, water, supercritical CO2, Ionic liquids,
III- Biocatalysis – Biomass
IV- Solids supported reaction/reagents, flow chemistry
V- Microwaves
VI- Multicomponent and cascade reactions
VII- Organocatalysis

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Details:

A. Molécules bioactives et médicaments : modes d’action et conceptions (5 cours, Benjamin Boucherle, UFR de Pharmacie)

Le médicament (1 cours) :
Définition et généralités ; Processus de recherche et développement des médicaments ; De la cible au candidat médicament préclinique ; Les essais cliniques ; Aspects règlementaires (AMM) ;
Petites molécules chimiques vs biomolécules

Introduction à la pharmacologie (3 cours)
Rappel de physiologie : Procaryote et eucaryote ; De la cellule à l’organisme
Pharmacologie : Définitions et concepts ; Ligand – cibles ; Agonistes et antagonistes ; Devenir in vivo des médicaments

Conception de médicament (1 cours)
Différents types de conception (basée sur le récepteur, basée sur le ligand, méthodes des fragments) ; Relation Structure-Activité ; Modélisation moléculaire (QSAR et amarrage moléculaire) ; Evaluations biochimiques des molécules bioactives

B. Exemple de grandes classe de médicaments
Objectifs : savoir reconnaitre les structures chimiques des molécules chefs de file étudiées, et reconnaitre les cibles biologiques des molécules chefs de file, connaitre le mécanisme d’action des molécules chefs de file.
Maitriser les approches de conception qui ont permis la mise au point de médicaments à partir de molécules chefs de file. Connaitre les éléments de bases liés à l’incidence de la métabolisation sur l’activité des molécules étudiées.
- Analgésiques (morphiniques et non morphiniques), Anesthésiques locaux, Anti-inflammatoires
- Médicaments du système nerveux central

C. Agents chimiothérapeutiques
Objectifs : à l'issue de ce cours, l'étudiant devra avoir une connaissance des éléments essentiels de la structure des principaux (ou principales familles de) principes actifs ainsi que de leur(s) cible(s) et leur(s) mécanisme(s) d'action(s).
- Anticancéreux : différentes approches, mécanismes d’action (agents alkylants, intercalants, nucléosides précurseurs d’inhibiteurs de la synthèse et de la modification de l’ADN, antimitotiques, etc....)
- Antiviraux : inhibiteurs de polymérases, de protéases…
- Antibiotiques :  sulfamides antibactériens, inhibiteurs de la synthèse des protéines, médicaments contre la tuberculose
- Antipaludéens

Objectifs :

à l'issue de ce cours, l'étudiant devra avoir une connaissance des éléments essentiels de la structure des principaux (ou principales familles de) principes actifs ainsi que de leur(s) cible(s) et leur(s) mécanisme(s) d'action(s).
- Anticancéreux : différentes approches, mécanismes d’action (agents alkylants, intercalants, nucléosides précurseurs d’inhibiteurs de la synthèse et de la modification de l’ADN, antimitotiques, etc....)
- Antiviraux : inhibiteurs de polymérases, de protéases…
- Antibiotiques :  sulfamides antibactériens, inhibiteurs de la synthèse des protéines, médicaments contre la tuberculose
- Antipaludéens

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Cette unité d’enseignement de 3 ECTS est enseignée en Français et est divisée en trois grandes parties : Gestion de projet, Propriété industrielle, Plans d’expérience.

Gestion de projet

Le cours se compose de deux parties :

1. Communication qui est la poursuite de l’UE Communication tools pour approfondir la connaissance de soi et savoir se présenter lors d’un entretien de recrutement

2. Gestion de projet: Initiation à la gestion entrepreneurial permettant d’avoir un aperçu des outils de gestion de projets, des bases en gestion
et en entrepreneuriat.

Propriété industrielle

Résumé du cours : principes fondamentaux des droits de propriété intellectuelle : conditions, effets et exceptions des droits de brevet, savoir-faire, marque, dessin et modèle, obtentions végétales, topographie des semi-conducteurs, de la contrefaçon.

Détails :
Droit du brevet : conditions de fond, de forme pour obtention du titre. Effets et limites du brevet, national et européen.
Droit de la marque : conditions de fond, de forme pour obtention du titre. Effets et limites de la marque, nationale et européenne.
Droit des dessins et modèles: conditions de fond, de forme pour obtention du titre. Effets et limites du titre, national et européen.
Principes des topographies de semi-conducteur, obtention végétales, droit d’auteur.
L’action en contrefaçon : la preuve, les démarches, les résultats.

Plans d’expériences

Résumé du cours : Le cours traite des principaux plans d’expériences habituellement rencontrés (plan factoriels complet, plan factoriels fractionnaire, plans pour surface de réponses). L’analyse statistique des plans d’expériences sera également abordée.

Détails : Le cours est constitué des 4 items suivant :

• Les plans factoriels complets
• Les plans factoriels fractionnaires
• Plan pour surface de réponses
• Traitement statistique des plans d’expériences

Visit the full page about this course

Visit the full page about this course

The aim of the M2 internship is to put all the theoretical and practical skills acquired by the students since their Bachelor's degrees into practice as they take part in a research or R&D project in a laboratory. The students will be entrusted with a clearly identified mission, and they will be responsible, firstly, for its completion, and secondly, for the presentation of the methods implemented and results obtained in a written report and through one or more oral presentations.

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The syllabus of the English course in M2 aims at enabling students to validate 3 competences that will be essential for their working life or for their doctoral studies in the future, at the B2 level: 1°) CAN give a clear presentation on a familiar topic, and CAN answer predictable or factual questions 2°) CAN find relevant information and essential points in written texts 3°) CAN make simple notes that are of reasonable use for essay or revision purposes, capturing most important points." (CEF, appendix D). Reading comprehension can be validated in M1. The course contents are linked to the students' fields of studies.

Visit the full page about this course

Choix d'un ETC si niveau anglais >= B2

Visit the full page about this course

The aim of the M2 internship is to put all the theoretical and practical skills acquired by the students since their Bachelor's degrees into practice as they take part in a research or R&D project in a laboratory. The students will be entrusted with a clearly identified mission, and they will be responsible, firstly, for its completion, and secondly, for the presentation of the methods implemented and results obtained in a written report and through one or more oral presentations.

Visit the full page about this course

The syllabus of the English course in M2 aims at enabling students to validate 3 competences that will be essential for their working life or for their doctoral studies in the future, at the B2 level: 1°) CAN give a clear presentation on a familiar topic, and CAN answer predictable or factual questions 2°) CAN find relevant information and essential points in written texts 3°) CAN make simple notes that are of reasonable use for essay or revision purposes, capturing most important points." (CEF, appendix D). Reading comprehension can be validated in M1. The course contents are linked to the students' fields of studies.

Visit the full page about this course

Choix d'un ETC si niveau anglais >= B2

Visit the full page about this course

Visit the full page about this course

This course will provide background on critical issues on the main pi-conjugated and conducting polymers used as the active materials for the electronics applications. The different methods of chemical, electrochemical synthesis and recent synthetic methodologies will be reviewed. We will discuss the underlying scientific principles that guide the study of structure-property relationships and the supramolecular effects on the modulation of electronic properties. Applications of these polymers in their undoped (organic light emitting diodes, organic solar cells, antistatic layers…) doped state (corrosion, actuators, electrochromic, sensors...) will be described.

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In this lecture, students learn polymeric materials for the applications in the medical field, especially their macromolecular structure and organization as well as structure-function relationships. The main families of synthetic and natural polymer materials used in living tissues and/or biological fluids are presented. Emphasis is placed on the properties and characterization of stimuli-responsive polymers and hydrogels that can sense specific biological signals and trigger a therapeutic action appropriate to local pathological or physiological environments. The course will be illustrated with applications in the field of controlled drug release and tissue engineering.

Visit the full page about this course

The main goal of this lecture is to provide the students with basic and sound knowledge of the structure/properties relationships in polymers and composites. A deep introduction is first given to understand the characteristic temperatures of polymeric materials, before studying heterogeneous structure. Polymer-polymer blends are explained through statistical thermodynamics, blends miscibility and phase diagrams, phase separation, interface between two immiscible polymers, copolymers and surfactants. The most common modelling methods are described for phase diagram calculation as well as homogenization, practical examples are treated by the students. The scaling effect and the practical improvement in properties that can be obtained from micro- and nanocomposites are also critically reviewed. The prominent ways to add values in polymers through functional properties are described both with practical illustrations and more conceptual description.

Visit the full page about this course

This course aims to define the different ageing mechanisms of polymers, stabilization strategies to improve their lifetime and finally address the problem of their recycling.

Visit the full page about this course

Course outline:

This course covers fundamental and applied aspects related to the formulation of polymer materials and to their application in the field of coatings and composite polymer materials.

Practical work:

Rheological study of physical hydrogels, solid state characterization of semi-crystalline polymers by optical microscopy, thermal characteristics determination of polymers by Differential Scanning Calorimetry (DSC), analysis of solid polymer materials (tensile characteristics and resistance impact), analysis of the elasticity and equilibrium swelling of polymer networks, Scanning Electron Microscopy (SEM) of polymer composites.

Visit the full page about this course

This course is devoted to the multiscale study of the structure of polymer materials using small angle scattering (SAS), nuclear magnetic resonance (NMR) and rheometry. Besides liquid-state NMR, the course explains how solid-state NMR can be applied to the characterization of polymers. Experimental tricks to obtain high-resolution ¹³C NMR spectra of solids are discussed. Dipolar interactions, chemical shifts anisotropy, magic angle spinning, relaxation times (T1 and T2 and T1g)  and cross-polarization are some of the main notions that are presented in the course. The course is based on examples that were studied with high-resolution solid state ¹³C  NMR. Regarding rheometry, the relationships between the (nano)structure of polymers and their use properties and implementation.

Visit the full page about this course

This course addresses the elaboration and characterizations of main polymer materials (polymer electrolytes, electrode binder, membranes, separators) for alternative energies: i.e. lithium batteries, redox flow batteries, fuel cells, super-capacitors, solar cells etc.  We will discuss on the impact of the chemical structures of polymers and membrane manufacturing conditions on the ion conductivity and cell performance. Specific polymers used in the manufacturing of membranes, separators, electrode binders as well active materials in electrode or electrolyte will be presented. The polymers can induce some limitations in the performances of different systems, these aspects will be reviewed and some solution reported in the literature will be discussed. 

Visit the full page about this course

The course provides an overview of biosourced polymers comprising most abundant natural polymers, bio-engineered polymers, and polymers synthesized fully or partially from biobased substrates. The structure, important properties, synthesis, and application is addressed. Technological and future challenges, potential solutions and the major industry players who are bringing these materials to market are discussed.

Visit the full page about this course

Cette UE est enseignée en Français.

Introduction au management de l’Hygiène, la Sécurité, l’Environnement au travail : aspects réglementaires (code du travail et code de l’environnement), principes d’évaluation des risques, Installations Classées pour la Protection de l’Environnement, prévention des risques au travail et environnementaux : en particulier en ce qui concerne le risque incendie, le risque électrique et les risques chimiques (étiquetage, FDS, dangers, équipements de protection, transport de matière dangereuse, etc…).

Détails:

1. Prévention des risques professionnels
2. Prévention des risques environnementaux
3. Les risques chimiques
4. Le risque incendie
5. Le risque électrique

Connaissance :
- des obligations en sécurité au travail (employeur et salariés),
- de techniques de prévention des risques,
- d’impacts environnementaux liés aux activités industrielles.

Gestion comptable:

Organisation du cours :

Les séances seront articulées autour d’une simulation de gestion pour aborder progressivement et empiriquement les notions suivantes :

1. Le Bilan
2. Le compte de résultat et la trésorerie
3. Les coûts de revient et les marges
4. Les seuils de rentabilité

Objectifs :
- S’approprier le vocabulaire de la comptabilité
- Savoir lire les documents comptables : bilan, compte de résultat
- Savoir analyser les principaux résultats financiers : rentabilité, solvabilité.
- Savoir calculer un coût de revient simple
- Savoir déterminer un seuil de rentabilité.

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Cette unité d’enseignement de 3 ECTS est enseignée en Français et est divisée en trois grandes parties : Gestion de projet, Propriété industrielle, Plans d’expérience.

Gestion de projet

Le cours se compose de deux parties :

1. Communication qui est la poursuite de l’UE Communication tools pour approfondir la connaissance de soi et savoir se présenter lors d’un entretien de recrutement

2. Gestion de projet: Initiation à la gestion entrepreneurial permettant d’avoir un aperçu des outils de gestion de projets, des bases en gestion
et en entrepreneuriat.

Propriété industrielle

Résumé du cours : principes fondamentaux des droits de propriété intellectuelle : conditions, effets et exceptions des droits de brevet, savoir-faire, marque, dessin et modèle, obtentions végétales, topographie des semi-conducteurs, de la contrefaçon.

Détails :
Droit du brevet : conditions de fond, de forme pour obtention du titre. Effets et limites du brevet, national et européen.
Droit de la marque : conditions de fond, de forme pour obtention du titre. Effets et limites de la marque, nationale et européenne.
Droit des dessins et modèles: conditions de fond, de forme pour obtention du titre. Effets et limites du titre, national et européen.
Principes des topographies de semi-conducteur, obtention végétales, droit d’auteur.
L’action en contrefaçon : la preuve, les démarches, les résultats.

Plans d’expériences

Résumé du cours : Le cours traite des principaux plans d’expériences habituellement rencontrés (plan factoriels complet, plan factoriels fractionnaire, plans pour surface de réponses). L’analyse statistique des plans d’expériences sera également abordée.

Détails : Le cours est constitué des 4 items suivant :

• Les plans factoriels complets
• Les plans factoriels fractionnaires
• Plan pour surface de réponses
• Traitement statistique des plans d’expériences

Visit the full page about this course

This course will provide background on critical issues on the main pi-conjugated and conducting polymers used as the active materials for the electronics applications. The different methods of chemical, electrochemical synthesis and recent synthetic methodologies will be reviewed. We will discuss the underlying scientific principles that guide the study of structure-property relationships and the supramolecular effects on the modulation of electronic properties. Applications of these polymers in their undoped (organic light emitting diodes, organic solar cells, antistatic layers…) doped state (corrosion, actuators, electrochromic, sensors...) will be described.

Visit the full page about this course

In this lecture, students learn polymeric materials for the applications in the medical field, especially their macromolecular structure and organization as well as structure-function relationships. The main families of synthetic and natural polymer materials used in living tissues and/or biological fluids are presented. Emphasis is placed on the properties and characterization of stimuli-responsive polymers and hydrogels that can sense specific biological signals and trigger a therapeutic action appropriate to local pathological or physiological environments. The course will be illustrated with applications in the field of controlled drug release and tissue engineering.

Visit the full page about this course

The main goal of this lecture is to provide the students with basic and sound knowledge of the structure/properties relationships in polymers and composites. A deep introduction is first given to understand the characteristic temperatures of polymeric materials, before studying heterogeneous structure. Polymer-polymer blends are explained through statistical thermodynamics, blends miscibility and phase diagrams, phase separation, interface between two immiscible polymers, copolymers and surfactants. The most common modelling methods are described for phase diagram calculation as well as homogenization, practical examples are treated by the students. The scaling effect and the practical improvement in properties that can be obtained from micro- and nanocomposites are also critically reviewed. The prominent ways to add values in polymers through functional properties are described both with practical illustrations and more conceptual description.

Visit the full page about this course

Course outline:

This course covers fundamental and applied aspects related to the formulation of polymer materials and to their application in the field of coatings and composite polymer materials.

Practical work:

Rheological study of physical hydrogels, solid state characterization of semi-crystalline polymers by optical microscopy, thermal characteristics determination of polymers by Differential Scanning Calorimetry (DSC), analysis of solid polymer materials (tensile characteristics and resistance impact), analysis of the elasticity and equilibrium swelling of polymer networks, Scanning Electron Microscopy (SEM) of polymer composites.

Visit the full page about this course

This course is devoted to the multiscale study of the structure of polymer materials using small angle scattering (SAS), nuclear magnetic resonance (NMR) and rheometry. Besides liquid-state NMR, the course explains how solid-state NMR can be applied to the characterization of polymers. Experimental tricks to obtain high-resolution ¹³C NMR spectra of solids are discussed. Dipolar interactions, chemical shifts anisotropy, magic angle spinning, relaxation times (T1 and T2 and T1g)  and cross-polarization are some of the main notions that are presented in the course. The course is based on examples that were studied with high-resolution solid state ¹³C  NMR. Regarding rheometry, the relationships between the (nano)structure of polymers and their use properties and implementation.

Visit the full page about this course

This course addresses the elaboration and characterizations of main polymer materials (polymer electrolytes, electrode binder, membranes, separators) for alternative energies: i.e. lithium batteries, redox flow batteries, fuel cells, super-capacitors, solar cells etc.  We will discuss on the impact of the chemical structures of polymers and membrane manufacturing conditions on the ion conductivity and cell performance. Specific polymers used in the manufacturing of membranes, separators, electrode binders as well active materials in electrode or electrolyte will be presented. The polymers can induce some limitations in the performances of different systems, these aspects will be reviewed and some solution reported in the literature will be discussed. 

Visit the full page about this course

The course provides an overview of biosourced polymers comprising most abundant natural polymers, bio-engineered polymers, and polymers synthesized fully or partially from biobased substrates. The structure, important properties, synthesis, and application is addressed. Technological and future challenges, potential solutions and the major industry players who are bringing these materials to market are discussed.

Visit the full page about this course

Visit the full page about this course

Course outline:

Common modelling methods based on classical (MM, MD) and quantal (HF, DFT) approaches are addressed and their application are illustrated during lectures. Three computational labs are made to make students familiar with the application of these methods.

Details:

I. Lect1- Introduction: The potential energy surface
II. Lect2- Molecular Mechanics, Forcefield methods
III. Lab1- Forcefield methods, exploration of a potential energy surface
IV. Lect3- Ab initio methods, the self-consistent field, basis sets, density functional theory and applications
V. Lab2- ab initio methods: electron structure, reactivity
VI. Lect4- Molecular Dynamics simulations
VII. Lab3- Molecular Dynamics Simulations

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Green chemsitry is a major evolution in organic chemistry for more efficient, sustainable transformations while minimizing by-products, solvents and waste. In this course, the 12 principle of green chemistry will be presented and illustrated through dedicated chapters to: solvents, catalysis, biotransformation, flow chemistry, organocatalysis and multicomponent and cascade reactions.

Details:

I – Introduction: History, E-factor, 12 principles
II- Solvents: greener solvent, no solvent, water, supercritical CO2, Ionic liquids,
III- Biocatalysis – Biomass
IV- Solids supported reaction/reagents, flow chemistry
V- Microwaves
VI- Multicomponent and cascade reactions
VII- Organocatalysis

Visit the full page about this course

This course aims to define the different ageing mechanisms of polymers, stabilization strategies to improve their lifetime and finally address the problem of their recycling.

Visit the full page about this course

Cette unité d’enseignement de 3 ECTS est enseignée en Français et est divisée en trois grandes parties : Gestion de projet, Propriété industrielle, Plans d’expérience.

Gestion de projet

Le cours se compose de deux parties :

1. Communication qui est la poursuite de l’UE Communication tools pour approfondir la connaissance de soi et savoir se présenter lors d’un entretien de recrutement

2. Gestion de projet: Initiation à la gestion entrepreneurial permettant d’avoir un aperçu des outils de gestion de projets, des bases en gestion
et en entrepreneuriat.

Propriété industrielle

Résumé du cours : principes fondamentaux des droits de propriété intellectuelle : conditions, effets et exceptions des droits de brevet, savoir-faire, marque, dessin et modèle, obtentions végétales, topographie des semi-conducteurs, de la contrefaçon.

Détails :
Droit du brevet : conditions de fond, de forme pour obtention du titre. Effets et limites du brevet, national et européen.
Droit de la marque : conditions de fond, de forme pour obtention du titre. Effets et limites de la marque, nationale et européenne.
Droit des dessins et modèles: conditions de fond, de forme pour obtention du titre. Effets et limites du titre, national et européen.
Principes des topographies de semi-conducteur, obtention végétales, droit d’auteur.
L’action en contrefaçon : la preuve, les démarches, les résultats.

Plans d’expériences

Résumé du cours : Le cours traite des principaux plans d’expériences habituellement rencontrés (plan factoriels complet, plan factoriels fractionnaire, plans pour surface de réponses). L’analyse statistique des plans d’expériences sera également abordée.

Détails : Le cours est constitué des 4 items suivant :

• Les plans factoriels complets
• Les plans factoriels fractionnaires
• Plan pour surface de réponses
• Traitement statistique des plans d’expériences

Visit the full page about this course

Visit the full page about this course

The aim of the M2 internship is to put all the theoretical and practical skills acquired by the students since their Bachelor's degrees into practice as they take part in a research or R&D project in a laboratory. The students will be entrusted with a clearly identified mission, and they will be responsible, firstly, for its completion, and secondly, for the presentation of the methods implemented and results obtained in a written report and through one or more oral presentations.

Visit the full page about this course

Visit the full page about this course

Choix d'un ETC si niveau anglais >= B2

Visit the full page about this course

The aim of the M2 internship is to put all the theoretical and practical skills acquired by the students since their Bachelor's degrees into practice as they take part in a research or R&D project in a laboratory. The students will be entrusted with a clearly identified mission, and they will be responsible, firstly, for its completion, and secondly, for the presentation of the methods implemented and results obtained in a written report and through one or more oral presentations.

Visit the full page about this course

Visit the full page about this course

Choix d'un ETC si niveau anglais >= B2

Visit the full page about this course

Visit the full page about this course

Visit the full page about this course

Course outline:

The principle of asymmetric synthesis is presented and illustrated by examples of asymmetric reduction of carbonyl, imines, alkenes, asymmetric oxydations, stereoselective alkylations, aldol reactions and stereoselective allylations. This asymmetric reaction toolbox set the basic knowledge to generate enantioenriched compounds, crucial for organic chemists. This course is also illustrated by the study of natural products asymmetric synthesis.

Details:

I. Principle of asymmetric synthesis, reminder on enantiomeric excess and absolute configuration, catalysis
II. Enantioselective reduction of C=O, C=N and C=C bonds
III. Asymmetric oxidation
IV. Enantioselective (2+1) and (4+2) cycloadditions
V. Enolates Formations; Stereoselective Alkylations, Stereoselective Aldol Reactions
VI. Stereoselective Allylations

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Course outline:

The total synthesis of a complex organic molecule, such as a drug or a bio-active natural product, may be a difficult task, especially if it contains a large number of carbon atoms, many functions (or, indeed, no function at all) and/or rings of various size. The way leading to the final target may be even harder to find if lots of stereogenic centers are present. Strategies to overcome such difficulties will be presented, both in a general perspective and in a series of examples selected whether for their interest in the history of total synthesis, or because they are representative of the most recent developments in the field.

Details:

1- General strategy
2- Alkene synthesis
3- Three-membered rings
4- Four-membered rings
5- Five-membered rings
6- Six-membered rings
7- Larger rings
8- Condensed rings
9- Silicon chemistry
10- Rearrangements

Throughout these chapters, lots of representative total syntheses (ca. 50) will be outlined, e.g. pheromones, morphine, taxol, penicillin, oseltamivir (Tamiflu), chlorophyll A …

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It is recognized that a large number of bioactive compounds are cyclic molecules containing one or several heteroatoms (N, O, S, …). In this course, the chemical properties of the most representative 6- and 5-membered rings and the major methods used for their synthesis will be reviewed. Especially, methods using organometallic chemistry will be discussed. Nomenclature rules will also be explained and exemplified.

Details:

I. Introduction General presentation and definitions
II. Nomenclature Rules
III. Structures of Heterocycles Structure-reactivity relationships
IV. Common Reaction Types in Aromatic Heterocyclic Chemistry Electrophilic substitution, Nucleophilic substitution, Organometallic Heterocyclic Chemistry
V. General Strategies for Heterocycle Synthesis
VI. Typical reactivity and Synthesis of 6-membered rings Pyridine, Benzopyridines, Diazines
VII. Typical reactivity and Synthesis of 5-membered rings Pyrrole, Furan, Thiophene, Azoles and their Benzofused analogs
VIII. Reactivity of Purines A combination of the 6- and 5-membered rings reactivity

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Course outline:

The main part of the course deals with the chemical development of an active ingredient (i.e. pharmaceutical ingredient or agrochemical) from milligrams to tons: how the discovery chemistry synthesis route evolves into a manufacturing process. Besides, several lessons aim to revive prior knowledge of industrial
organic chemistry, with emphasis on the connections between raw materials, commodity chemicals and applications.

Details:

- The chemical development of a bioactive compound is first addressed through an open discussion. Students then work individually and in small teams to gather informations from selected publications. Their reports to the class allow all students to discover important aspects of chemical development. The topic is later on presented extensively by professionals from the industry (lectures). Tutorials dealing especially with the safety of chemical processes complete the course.

- After a brief overview of the business sectors related to chemistry and the sources of organic chemicals (petroleum, coal, biomass), selected end products are traced back to the commodity chemical they are synthesized from, and further to the raw materials (quiz and lectures).

Visit the full page about this course

Green chemsitry is a major evolution in organic chemistry for more efficient, sustainable transformations while minimizing by-products, solvents and waste. In this course, the 12 principle of green chemistry will be presented and illustrated through dedicated chapters to: solvents, catalysis, biotransformation, flow chemistry, organocatalysis and multicomponent and cascade reactions.

Details:

I – Introduction: History, E-factor, 12 principles
II- Solvents: greener solvent, no solvent, water, supercritical CO2, Ionic liquids,
III- Biocatalysis – Biomass
IV- Solids supported reaction/reagents, flow chemistry
V- Microwaves
VI- Multicomponent and cascade reactions
VII- Organocatalysis

Visit the full page about this course

Details:

A. Molécules bioactives et médicaments : modes d’action et conceptions (5 cours, Benjamin Boucherle, UFR de Pharmacie)

Le médicament (1 cours) :
Définition et généralités ; Processus de recherche et développement des médicaments ; De la cible au candidat médicament préclinique ; Les essais cliniques ; Aspects règlementaires (AMM) ;
Petites molécules chimiques vs biomolécules

Introduction à la pharmacologie (3 cours)
Rappel de physiologie : Procaryote et eucaryote ; De la cellule à l’organisme
Pharmacologie : Définitions et concepts ; Ligand – cibles ; Agonistes et antagonistes ; Devenir in vivo des médicaments

Conception de médicament (1 cours)
Différents types de conception (basée sur le récepteur, basée sur le ligand, méthodes des fragments) ; Relation Structure-Activité ; Modélisation moléculaire (QSAR et amarrage moléculaire) ; Evaluations biochimiques des molécules bioactives

B. Exemple de grandes classe de médicaments
Objectifs : savoir reconnaitre les structures chimiques des molécules chefs de file étudiées, et reconnaitre les cibles biologiques des molécules chefs de file, connaitre le mécanisme d’action des molécules chefs de file.
Maitriser les approches de conception qui ont permis la mise au point de médicaments à partir de molécules chefs de file. Connaitre les éléments de bases liés à l’incidence de la métabolisation sur l’activité des molécules étudiées.
- Analgésiques (morphiniques et non morphiniques), Anesthésiques locaux, Anti-inflammatoires
- Médicaments du système nerveux central

C. Agents chimiothérapeutiques
Objectifs : à l'issue de ce cours, l'étudiant devra avoir une connaissance des éléments essentiels de la structure des principaux (ou principales familles de) principes actifs ainsi que de leur(s) cible(s) et leur(s) mécanisme(s) d'action(s).
- Anticancéreux : différentes approches, mécanismes d’action (agents alkylants, intercalants, nucléosides précurseurs d’inhibiteurs de la synthèse et de la modification de l’ADN, antimitotiques, etc....)
- Antiviraux : inhibiteurs de polymérases, de protéases…
- Antibiotiques :  sulfamides antibactériens, inhibiteurs de la synthèse des protéines, médicaments contre la tuberculose
- Antipaludéens

Objectifs :

à l'issue de ce cours, l'étudiant devra avoir une connaissance des éléments essentiels de la structure des principaux (ou principales familles de) principes actifs ainsi que de leur(s) cible(s) et leur(s) mécanisme(s) d'action(s).
- Anticancéreux : différentes approches, mécanismes d’action (agents alkylants, intercalants, nucléosides précurseurs d’inhibiteurs de la synthèse et de la modification de l’ADN, antimitotiques, etc....)
- Antiviraux : inhibiteurs de polymérases, de protéases…
- Antibiotiques :  sulfamides antibactériens, inhibiteurs de la synthèse des protéines, médicaments contre la tuberculose
- Antipaludéens

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Cette UE est enseignée en Français.

Introduction au management de l’Hygiène, la Sécurité, l’Environnement au travail : aspects réglementaires (code du travail et code de l’environnement), principes d’évaluation des risques, Installations Classées pour la Protection de l’Environnement, prévention des risques au travail et environnementaux : en particulier en ce qui concerne le risque incendie, le risque électrique et les risques chimiques (étiquetage, FDS, dangers, équipements de protection, transport de matière dangereuse, etc…).

Détails:

1. Prévention des risques professionnels
2. Prévention des risques environnementaux
3. Les risques chimiques
4. Le risque incendie
5. Le risque électrique

Connaissance :
- des obligations en sécurité au travail (employeur et salariés),
- de techniques de prévention des risques,
- d’impacts environnementaux liés aux activités industrielles.

Gestion comptable:

Organisation du cours :

Les séances seront articulées autour d’une simulation de gestion pour aborder progressivement et empiriquement les notions suivantes :

1. Le Bilan
2. Le compte de résultat et la trésorerie
3. Les coûts de revient et les marges
4. Les seuils de rentabilité

Objectifs :
- S’approprier le vocabulaire de la comptabilité
- Savoir lire les documents comptables : bilan, compte de résultat
- Savoir analyser les principaux résultats financiers : rentabilité, solvabilité.
- Savoir calculer un coût de revient simple
- Savoir déterminer un seuil de rentabilité.

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Cette unité d’enseignement de 3 ECTS est enseignée en Français et est divisée en trois grandes parties : Gestion de projet, Propriété industrielle, Plans d’expérience.

Gestion de projet

Le cours se compose de deux parties :

1. Communication qui est la poursuite de l’UE Communication tools pour approfondir la connaissance de soi et savoir se présenter lors d’un entretien de recrutement

2. Gestion de projet: Initiation à la gestion entrepreneurial permettant d’avoir un aperçu des outils de gestion de projets, des bases en gestion
et en entrepreneuriat.

Propriété industrielle

Résumé du cours : principes fondamentaux des droits de propriété intellectuelle : conditions, effets et exceptions des droits de brevet, savoir-faire, marque, dessin et modèle, obtentions végétales, topographie des semi-conducteurs, de la contrefaçon.

Détails :
Droit du brevet : conditions de fond, de forme pour obtention du titre. Effets et limites du brevet, national et européen.
Droit de la marque : conditions de fond, de forme pour obtention du titre. Effets et limites de la marque, nationale et européenne.
Droit des dessins et modèles: conditions de fond, de forme pour obtention du titre. Effets et limites du titre, national et européen.
Principes des topographies de semi-conducteur, obtention végétales, droit d’auteur.
L’action en contrefaçon : la preuve, les démarches, les résultats.

Plans d’expériences

Résumé du cours : Le cours traite des principaux plans d’expériences habituellement rencontrés (plan factoriels complet, plan factoriels fractionnaire, plans pour surface de réponses). L’analyse statistique des plans d’expériences sera également abordée.

Détails : Le cours est constitué des 4 items suivant :

• Les plans factoriels complets
• Les plans factoriels fractionnaires
• Plan pour surface de réponses
• Traitement statistique des plans d’expériences

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Course outline:

The principle of asymmetric synthesis is presented and illustrated by examples of asymmetric reduction of carbonyl, imines, alkenes, asymmetric oxydations, stereoselective alkylations, aldol reactions and stereoselective allylations. This asymmetric reaction toolbox set the basic knowledge to generate enantioenriched compounds, crucial for organic chemists. This course is also illustrated by the study of natural products asymmetric synthesis.

Details:

I. Principle of asymmetric synthesis, reminder on enantiomeric excess and absolute configuration, catalysis
II. Enantioselective reduction of C=O, C=N and C=C bonds
III. Asymmetric oxidation
IV. Enantioselective (2+1) and (4+2) cycloadditions
V. Enolates Formations; Stereoselective Alkylations, Stereoselective Aldol Reactions
VI. Stereoselective Allylations

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Course outline:

The total synthesis of a complex organic molecule, such as a drug or a bio-active natural product, may be a difficult task, especially if it contains a large number of carbon atoms, many functions (or, indeed, no function at all) and/or rings of various size. The way leading to the final target may be even harder to find if lots of stereogenic centers are present. Strategies to overcome such difficulties will be presented, both in a general perspective and in a series of examples selected whether for their interest in the history of total synthesis, or because they are representative of the most recent developments in the field.

Details:

1- General strategy
2- Alkene synthesis
3- Three-membered rings
4- Four-membered rings
5- Five-membered rings
6- Six-membered rings
7- Larger rings
8- Condensed rings
9- Silicon chemistry
10- Rearrangements

Throughout these chapters, lots of representative total syntheses (ca. 50) will be outlined, e.g. pheromones, morphine, taxol, penicillin, oseltamivir (Tamiflu), chlorophyll A …

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It is recognized that a large number of bioactive compounds are cyclic molecules containing one or several heteroatoms (N, O, S, …). In this course, the chemical properties of the most representative 6- and 5-membered rings and the major methods used for their synthesis will be reviewed. Especially, methods using organometallic chemistry will be discussed. Nomenclature rules will also be explained and exemplified.

Details:

I. Introduction General presentation and definitions
II. Nomenclature Rules
III. Structures of Heterocycles Structure-reactivity relationships
IV. Common Reaction Types in Aromatic Heterocyclic Chemistry Electrophilic substitution, Nucleophilic substitution, Organometallic Heterocyclic Chemistry
V. General Strategies for Heterocycle Synthesis
VI. Typical reactivity and Synthesis of 6-membered rings Pyridine, Benzopyridines, Diazines
VII. Typical reactivity and Synthesis of 5-membered rings Pyrrole, Furan, Thiophene, Azoles and their Benzofused analogs
VIII. Reactivity of Purines A combination of the 6- and 5-membered rings reactivity

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Green chemsitry is a major evolution in organic chemistry for more efficient, sustainable transformations while minimizing by-products, solvents and waste. In this course, the 12 principle of green chemistry will be presented and illustrated through dedicated chapters to: solvents, catalysis, biotransformation, flow chemistry, organocatalysis and multicomponent and cascade reactions.

Details:

I – Introduction: History, E-factor, 12 principles
II- Solvents: greener solvent, no solvent, water, supercritical CO2, Ionic liquids,
III- Biocatalysis – Biomass
IV- Solids supported reaction/reagents, flow chemistry
V- Microwaves
VI- Multicomponent and cascade reactions
VII- Organocatalysis

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Course outline:

Common modelling methods based on classical (MM, MD) and quantal (HF, DFT) approaches are addressed and their application are illustrated during lectures. Three computational labs are made to make students familiar with the application of these methods.

Details:

I. Lect1- Introduction: The potential energy surface
II. Lect2- Molecular Mechanics, Forcefield methods
III. Lab1- Forcefield methods, exploration of a potential energy surface
IV. Lect3- Ab initio methods, the self-consistent field, basis sets, density functional theory and applications
V. Lab2- ab initio methods: electron structure, reactivity
VI. Lect4- Molecular Dynamics simulations
VII. Lab3- Molecular Dynamics Simulations

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Details:

A. Molécules bioactives et médicaments : modes d’action et conceptions (5 cours, Benjamin Boucherle, UFR de Pharmacie)

Le médicament (1 cours) :
Définition et généralités ; Processus de recherche et développement des médicaments ; De la cible au candidat médicament préclinique ; Les essais cliniques ; Aspects règlementaires (AMM) ;
Petites molécules chimiques vs biomolécules

Introduction à la pharmacologie (3 cours)
Rappel de physiologie : Procaryote et eucaryote ; De la cellule à l’organisme
Pharmacologie : Définitions et concepts ; Ligand – cibles ; Agonistes et antagonistes ; Devenir in vivo des médicaments

Conception de médicament (1 cours)
Différents types de conception (basée sur le récepteur, basée sur le ligand, méthodes des fragments) ; Relation Structure-Activité ; Modélisation moléculaire (QSAR et amarrage moléculaire) ; Evaluations biochimiques des molécules bioactives

B. Exemple de grandes classe de médicaments
Objectifs : savoir reconnaitre les structures chimiques des molécules chefs de file étudiées, et reconnaitre les cibles biologiques des molécules chefs de file, connaitre le mécanisme d’action des molécules chefs de file.
Maitriser les approches de conception qui ont permis la mise au point de médicaments à partir de molécules chefs de file. Connaitre les éléments de bases liés à l’incidence de la métabolisation sur l’activité des molécules étudiées.
- Analgésiques (morphiniques et non morphiniques), Anesthésiques locaux, Anti-inflammatoires
- Médicaments du système nerveux central

C. Agents chimiothérapeutiques
Objectifs : à l'issue de ce cours, l'étudiant devra avoir une connaissance des éléments essentiels de la structure des principaux (ou principales familles de) principes actifs ainsi que de leur(s) cible(s) et leur(s) mécanisme(s) d'action(s).
- Anticancéreux : différentes approches, mécanismes d’action (agents alkylants, intercalants, nucléosides précurseurs d’inhibiteurs de la synthèse et de la modification de l’ADN, antimitotiques, etc....)
- Antiviraux : inhibiteurs de polymérases, de protéases…
- Antibiotiques :  sulfamides antibactériens, inhibiteurs de la synthèse des protéines, médicaments contre la tuberculose
- Antipaludéens

Objectifs :

à l'issue de ce cours, l'étudiant devra avoir une connaissance des éléments essentiels de la structure des principaux (ou principales familles de) principes actifs ainsi que de leur(s) cible(s) et leur(s) mécanisme(s) d'action(s).
- Anticancéreux : différentes approches, mécanismes d’action (agents alkylants, intercalants, nucléosides précurseurs d’inhibiteurs de la synthèse et de la modification de l’ADN, antimitotiques, etc....)
- Antiviraux : inhibiteurs de polymérases, de protéases…
- Antibiotiques :  sulfamides antibactériens, inhibiteurs de la synthèse des protéines, médicaments contre la tuberculose
- Antipaludéens

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Course outline:

The main part of the course deals with the chemical development of an active ingredient (i.e. pharmaceutical ingredient or agrochemical) from milligrams to tons: how the discovery chemistry synthesis route evolves into a manufacturing process. Besides, several lessons aim to revive prior knowledge of industrial
organic chemistry, with emphasis on the connections between raw materials, commodity chemicals and applications.

Details:

- The chemical development of a bioactive compound is first addressed through an open discussion. Students then work individually and in small teams to gather informations from selected publications. Their reports to the class allow all students to discover important aspects of chemical development. The topic is later on presented extensively by professionals from the industry (lectures). Tutorials dealing especially with the safety of chemical processes complete the course.

- After a brief overview of the business sectors related to chemistry and the sources of organic chemicals (petroleum, coal, biomass), selected end products are traced back to the commodity chemical they are synthesized from, and further to the raw materials (quiz and lectures).

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Course outline:

This course describes synthetic approaches and methods for: the synthesis of library of small[1]molecules, the assembly of peptide and analogs, the engineering of molecular conjugates of biomolecules, and the applications of that family of molecules in therapeutics, diagnostics and nanotechnologies (i.e. biosensors).

Details:

1/ Peptides and protein engineering

I.Structural aspects

II.Synthetic strategies (SPPS, fragment synthesis, native ligation)

III.Applications in vectorization (Monoclonal antibodies, cell-penetrating peptides, peptide ligands, nanoparticles)

IV.Antimicrobial peptides, toxins

V.Pseudopeptides

2/ Chemical ligation

I. The different reactions

II.Multiple chemoselective ligations

III.Installing bioorthogonal functionality into target biomolecules

IV.In vivo click chemistry

3/ Combinatorial chemistry

I. Drug Discovery

II.Synthetic strategies (combinatorial vs parallel synthesis; solid vs supported synthesis)

III.Dynamic Combinatorial Chemistry / Target guided synthesis

4/ Biosensors

I. Medicinal, environment and food safety applications

II.Biomolecules for molecular recognition

III.Chemical modifications for immobilization and transduction

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Cette unité d’enseignement de 3 ECTS est enseignée en Français et est divisée en trois grandes parties : Gestion de projet, Propriété industrielle, Plans d’expérience.

Gestion de projet

Le cours se compose de deux parties :

1. Communication qui est la poursuite de l’UE Communication tools pour approfondir la connaissance de soi et savoir se présenter lors d’un entretien de recrutement

2. Gestion de projet: Initiation à la gestion entrepreneurial permettant d’avoir un aperçu des outils de gestion de projets, des bases en gestion
et en entrepreneuriat.

Propriété industrielle

Résumé du cours : principes fondamentaux des droits de propriété intellectuelle : conditions, effets et exceptions des droits de brevet, savoir-faire, marque, dessin et modèle, obtentions végétales, topographie des semi-conducteurs, de la contrefaçon.

Détails :
Droit du brevet : conditions de fond, de forme pour obtention du titre. Effets et limites du brevet, national et européen.
Droit de la marque : conditions de fond, de forme pour obtention du titre. Effets et limites de la marque, nationale et européenne.
Droit des dessins et modèles: conditions de fond, de forme pour obtention du titre. Effets et limites du titre, national et européen.
Principes des topographies de semi-conducteur, obtention végétales, droit d’auteur.
L’action en contrefaçon : la preuve, les démarches, les résultats.

Plans d’expériences

Résumé du cours : Le cours traite des principaux plans d’expériences habituellement rencontrés (plan factoriels complet, plan factoriels fractionnaire, plans pour surface de réponses). L’analyse statistique des plans d’expériences sera également abordée.

Détails : Le cours est constitué des 4 items suivant :

• Les plans factoriels complets
• Les plans factoriels fractionnaires
• Plan pour surface de réponses
• Traitement statistique des plans d’expériences

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The aim of the M2 internship is to put all the theoretical and practical skills acquired by the students since their Bachelor's degrees into practice as they take part in a research or R&D project in a laboratory (program R) or company (program P). The students will be entrusted with a clearly identified mission, and they will be responsible, firstly, for its completion, and secondly, for the presentation of the methods implemented and results obtained in a written report and through one or more oral presentations.

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The syllabus of the English course in M2 aims at enabling students to validate 3 competences that will be essential for their working life or for their doctoral studies in the future, at the B2 level:

1°) CAN give a clear presentation on a familiar topic, and CAN answer predictable or factual questions

2°) CAN find relevant information and essential points in written texts

3°) CAN make simple notes that are of reasonable use for essay or revision purposes, capturing most important points." (CEF, appendix D).

Reading comprehension can be validated in M1.

The course contents are linked to the students' fields of studies.

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Choix d'un ETC si niveau anglais >= B2

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The aim of the M2 internship is to put all the theoretical and practical skills acquired by the students since their Bachelor's degrees into practice as they take part in a research or R&D project in a laboratory (program R) or company (program P). The students will be entrusted with a clearly identified mission, and they will be responsible, firstly, for its completion, and secondly, for the presentation of the methods implemented and results obtained in a written report and through one or more oral presentations.

Visit the full page about this course

The syllabus of the English course in M2 aims at enabling students to validate 3 competences that will be essential for their working life or for their doctoral studies in the future, at the B2 level:

1°) CAN give a clear presentation on a familiar topic, and CAN answer predictable or factual questions

2°) CAN find relevant information and essential points in written texts

3°) CAN make simple notes that are of reasonable use for essay or revision purposes, capturing most important points." (CEF, appendix D).

Reading comprehension can be validated in M1.

The course contents are linked to the students' fields of studies.

Visit the full page about this course

Choix d'un ETC si niveau anglais >= B2

Visit the full page about this course

Visit the full page about this course

Visit the full page about this course