Degrees incorporating this pedagocial element :
Description
Course outline:
This course describes synthetic approaches and methods for: the synthesis of library of small[1]molecules, the assembly of peptide and analogs, the engineering of molecular conjugates of biomolecules, and the applications of that family of molecules in therapeutics, diagnostics and nanotechnologies (i.e. biosensors).
Details:
1/ Peptides and protein engineering
I.Structural aspects
II.Synthetic strategies (SPPS, fragment synthesis, native ligation)
III.Applications in vectorization (Monoclonal antibodies, cell-penetrating peptides, peptide ligands, nanoparticles)
IV.Antimicrobial peptides, toxins
V.Pseudopeptides
2/ Chemical ligation
I. The different reactions
II.Multiple chemoselective ligations
III.Installing bioorthogonal functionality into target biomolecules
IV.In vivo click chemistry
3/ Combinatorial chemistry
I. Drug Discovery
II.Synthetic strategies (combinatorial vs parallel synthesis; solid vs supported synthesis)
III.Dynamic Combinatorial Chemistry / Target guided synthesis
4/ Biosensors
I. Medicinal, environment and food safety applications
II.Biomolecules for molecular recognition
III.Chemical modifications for immobilization and transduction
In brief
Period : Semester 9Credits : 3
Number of hours
- Lectures (CM) : 20h
Location(s) : Grenoble
Language(s) : English
Contact(s)
Eric Defrancq