UE Organic chemistry 2

Degrees incorporating this pedagocial element :


This course is divided in four main parts. The first part focusses on physical chemistry , necessary for a good understanding of chemical transformation. In the second part the chemistry of enolates will be detailed through the study of major reactions: alkylation, aldol, Claisen and 1-4 addition reactions. In the third part, pericyclic reactions will be studied (electrocyclic, cycloaddition and sigmatropic reactions). Finally the chemistry of free radicals and carbenes will be introduced. The course includes formal lectures and tutorial classes.

Recommended prerequisite

Organic chemistry I (taught in M1 first semester) or equivalent knowledge of organic
chemistry bases.

Targeted skills

Knowledge of common reactions in organic chemistry, of their mechanism and of their uses in total synthesis.


I. General Backgrounds
Acids and bases, thermodynamics and kinetics applied to organic reactions…
II. Enolate Chemistry Alkylation reaction, aldol condensation, acylation reactions, 1,4-additions
III. Pericyclic Reactions Woodward Hoffmann rules, cycloadditions (Diels-Alder, [2+2], …), sigmatropic rearrangements
IV. Reactive Intermediates Free radicals, carbenes
V. Organometallics