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    UE Asymmetric synthesis

    • ECTS

      6 credits

    • Component

      UFR Chimie-Biologie

    • Semester

      Tous les ans

    Description

    Course outline:

    The principle of asymmetric synthesis is presented and illustrated by examples of asymmetric reduction of carbonyl, imines, alkenes, asymmetric oxydations, stereoselective alkylations, aldol reactions and stereoselective allylations. This asymmetric reaction toolbox set the basic knowledge to generate enantioenriched compounds, crucial for organic chemists. This course is also illustrated by the study of natural products asymmetric synthesis.

     

    Details:


    I. Principle of asymmetric synthesis, reminder on enantiomeric excess and absolute configuration, catalysis
    II. Enantioselective reduction of C=O, C=N and C=C bonds
    III. Asymmetric oxidation
    IV. Enantioselective (2+1) and (4+2) cycloadditions
    V. Enolates Formations; Stereoselective Alkylations, Stereoselective Aldol Reactions
    VI. Stereoselective Allylations

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    Course parts

    • UE Asymmetric synthesis - CMLectures (CM)36h
    • TDTutorials (TD)4,5h

    Recommended prerequisites

    Prerequisites:

    Master 1 Organic chemistry 1 and 2

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    Period

    Semester 9

    Skills

    Skills:

    - Determining enantiomeric excesses and absolute configuration

    - Knowledge of the principal asymmetric transformations

    - Recognizing the interactions involved in the stereo-selection.

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