Chemistry 1st year

The purpose of this course is to further teach experimental chemsitry to the student  by working on synthetic projects during which they will reinforce their experimental knowledge. The students will first have to find, via  bibliographic research, the experimetnal procedure they will then set up and conduce during a full week of work in the laboratory.

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The goal of this course is to give chemists a solid theoretical (through lectures) and practical (through tutorials) background and know how in chemical analysis. Building on previous introductory undergraduate classes, the course will study more specifically the diverse purification and separation chromatographic technics, and the methods used to characterize chemical samples by mass spectrometry, atomic absorption, optical spectroscopies (infrared, Raman, UV-visible, fluorescence, X-ray diffraction) and magnetic spectroscopies (NMR and EPR). The spectroscopic approaches will be developed for structural studies of isolated molecules in solution or in the solid state. Techniques used to characterize intermolecular interaction and molecular reactivity of organic, inorganic or polymer materials will also be investigated.

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During this  course  a non-exhaustive way the various classes of protective group as well as their selective deprotection will be presented. Their use in chemistry of sugars, peptides and in total synthesis will be particularly exposed. The main reactions of oxidation, reduction and olefination will then be detailed through their mechanisms and selectivities.

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The purpose of this course is to teach students reaction involving organometallic species. It will include electronic   structures of complexes, elementary organometallic reactions and then their use in synthesis  (organo-lithium, -magnesium , -zinc, -copper/ hydrogenations/ cross coupling/metal-carbenes complexes/metal polyenes/  C-H activation).

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This course gives an overview of the polymer field from the synthesis of polymers to characterization, properties, and applications of synthetic and natural polymers. All major polymerization methods, their reaction mechanisms and kinetic aspects are considered: step growth polymerization, chain growth polymerization with ionic and radical variations, insertion polymerization. A lecture portion is integrated with a laboratory component, in which experiments are conducted that are directly connected to the class work. Analysis of  polymer solution properties and caracterization techniques are presented :  thermodynamics, polymer/solvent interactions, average molecular weight determination via osmometry, ligth scattering, viscosimetry and SEC.

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This course focuses on the chemistry, i.e. synthesis and reactivity, of peptides and saccharides. The basics of their synthesis will be first reviewed. Specific interactions of metal ions with those biomolecules will be then discussed as they play very important role in their structuration and function and thus in health and medicine.

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The Master 1 internship is a key moment in the evolution and orientation of the student during the master. Placed at the end of the year, in an academic laboratory or in a company, this internship will last at least 8 weeks in France, and up to 12 weeks for an internship abroad.

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This course is divided in four main parts. The first part focusses on physical chemistry , necessary for a good understanding of chemical transformation. In the second part the chemistry of enolates will be detailed through the study of major reactions: alkylation, aldol, Claisen and 1-4 addition reactions. In the third part, pericyclic reactions will be studied (electrocyclic, cycloaddition and sigmatropic reactions). Finally the chemistry of free radicals and carbenes will be introduced. The course includes formal lectures and tutorial classes.

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This teaching block is divided into two sections, bioinorganic chemistry and bioorganic chemistry. Bioorganic chemistry part is focused on the heterocycles chemistry mainly nitrogen(s) containing compounds (i.e. pyridines, pyrimidines, pyrroles, purines and nucleosides). Indeed heterocyclic compounds represent interesting organic compounds as they are involved in the design of many pharmaceutics as well as in biological processes. An overview of the roles that are played by the metal ions in life (biotransformations, dioxygen transport, drug elimination) and specially in the stabilization of nucleic acids will then be presented.

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This course gives an overview of the polymer field from the synthesis of polymers to characterization, properties, and applications of synthetic and natural polymers. All major polymerization methods, their reaction mechanisms and kinetic aspects are considered: step growth polymerization, chain growth polymerization with ionic and radical variations, insertion polymerization. A lecture portion is integrated with a laboratory component, in which experiments are conducted that are directly connected to the class work. Analysis of  polymer solution properties and caracterization techniques are presented :  thermodynamics, polymer/solvent interactions, average molecular weight determination via osmometry, ligth scattering, viscosimetry and SEC.

This course is divided in two parts covering selected aspects of polymer chemistry and physical chemistry. The chemistry part aims to help students better understand contemporary polymer science focusing on syntheses and materials properties of polymers. It covers copolymer synthesis, discussing control of copolymer composition and relevant recent research such as controlled radical polymerization, supramolecular polymers and bio-based polymers. The course will also provide detailed information for polymerization techniques and polymer characterization tools.

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The course will present the experimental strategies used to produce macromolecular samples for biophysical, structural studies and biotechnical applications, from bioinformatics analysis to recombinant protein expression systems, automation (robotics), purification and engineering and measurement of sample quality. Expected competences acquired by the students: expertise in bioinformatic analysis of macromolecule sequence and structure, understanding methods and strategies used to express and purify macromolecules, expertise in experimental methods used for sample quality control, practical experience on platforms on the EPN Campus.

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The lab project "organic syntheses" or  “Polymer” or "Chemistry of Life Science" is a one-week immersion into the world of research labs. Students will have to focus on specific objectives: total synthesis, synthesis of ligands, synthesis of polymer, asymmetric catalysis … They will have to carry out bibliography searching, compare the available methods, plan the synthesis (reactants and solvents needed) as well as establishing a suitable retrosynthesis. An important part of characterization of the products will be realised, in particular in the lab project “Polymer”.

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The English class in M1 chemistry aims at enabling students to find relevant information and main points in academic written texts quickly, to communicate on the basis of research articles in chemistry and to prepare and present scientific posters in their fields of studies.

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