Degrees incorporating this pedagocial element :
Description
It is recognized that a large number of bioactive compounds are cyclic molecules containing one or several heteroatoms (N, O, S, …). In this course, the chemical properties of the most representative 6- and 5-membered rings and the major methods used for their synthesis will be reviewed. Especially, methods using organometallic chemistry will be discussed. Nomenclature rules will also be explained and exemplified.
Details:
I. Introduction General presentation and definitions
II. Nomenclature Rules
III. Structures of Heterocycles Structure-reactivity relationships
IV. Common Reaction Types in Aromatic Heterocyclic Chemistry Electrophilic substitution, Nucleophilic substitution, Organometallic Heterocyclic Chemistry
V. General Strategies for Heterocycle Synthesis
VI. Typical reactivity and Synthesis of 6-membered rings Pyridine, Benzopyridines, Diazines
VII. Typical reactivity and Synthesis of 5-membered rings Pyrrole, Furan, Thiophene, Azoles and their Benzofused analogs
VIII. Reactivity of Purines A combination of the 6- and 5-membered rings reactivity
Recommended prerequisite
Prerequisites:
Organic chemistry and Benzene chemistry (bachelor program, CHI501 and CHI601). Some basics in organometallic chemistry will be appreciated.
Targeted skills
Skills:
Knowledge of the typical reactivity and synthesis methods of the most representative rings using classical and modern heterocyclic chemistry.
In brief
Period : Semester 9Credits : 3
Number of hours
- Lectures (CM) : 27h
- Tutorials (TD) : 3h
Language(s) : English
Contact(s)
Sabine Chierici