UE Heterocyclic chemistry

Diplômes intégrant cet élément pédagogique :


It is recognized that a large number of bioactive compounds are cyclic molecules containing one or several heteroatoms (N, O, S, …). In this course, the chemical properties of the most representative 6- and 5-membered rings and the major methods used for their synthesis will be reviewed. Especially, methods using organometallic chemistry will be discussed. Nomenclature rules will also be explained and exemplified.



I. Introduction General presentation and definitions
II. Nomenclature Rules
III. Structures of Heterocycles Structure-reactivity relationships
IV. Common Reaction Types in Aromatic Heterocyclic Chemistry Electrophilic substitution, Nucleophilic substitution, Organometallic Heterocyclic Chemistry
V. General Strategies for Heterocycle Synthesis
VI. Typical reactivity and Synthesis of 6-membered rings Pyridine, Benzopyridines, Diazines
VII. Typical reactivity and Synthesis of 5-membered rings Pyrrole, Furan, Thiophene, Azoles and their Benzofused analogs
VIII. Reactivity of Purines A combination of the 6- and 5-membered rings reactivity

Pré-requis recommandés


Organic chemistry and Benzene chemistry (bachelor program, CHI501 and CHI601). Some basics in organometallic chemistry will be appreciated.

Compétences visées


Knowledge of the typical reactivity and synthesis methods of the most representative rings using classical and modern heterocyclic chemistry.

Informations complémentaires

Lieu(x) : Grenoble
Langue(s) : Anglais