Catalogue des formations

Diplômes intégrant cet élément pédagogique :

• Master Chimie

Descriptif

Course outline:

The principle of asymmetric synthesis is presented and illustrated by examples of asymmetric reduction of carbonyl, imines, alkenes, asymmetric oxydations, stereoselective alkylations, aldol reactions and stereoselective allylations. This asymmetric reaction toolbox set the basic knowledge to generate enantioenriched compounds, crucial for organic chemists. This course is also illustrated by the study of natural products asymmetric synthesis.

 

Details:

I. Principle of asymmetric synthesis, reminder on enantiomeric excess and absolute configuration, catalysis
II. Enantioselective reduction of C=O, C=N and C=C bonds
III. Asymmetric oxidation
IV. Enantioselective (2+1) and (4+2) cycloadditions
V. Enolates Formations; Stereoselective Alkylations, Stereoselective Aldol Reactions
VI. Stereoselective Allylations

Pré-requis recommandés

Prerequisites:

Master 1 Organic chemistry 1 and 2

Compétences visées

Skills:

- Determining enantiomeric excesses and absolute configuration

- Knowledge of the principal asymmetric transformations

- Recognizing the interactions involved in the stereo-selection.

Informations complémentaires

Lieu(x) : Grenoble
Langue(s) : Français, Anglais