UE Heterocyclic chemistry

CHI948 – Heterocyclic Chemistry      
Contact: Dr Sabine Chierici, sabine.chierici@univ-grenoble-alpes.fr

Language of teaching: English
Master program including this course: M2 Organic Synthesis and M2 CLS    
Teaching period: M2 Fall semester (September to December)
Credits: 3 ECTS
Prerequisites: Organic chemistry and Benzene chemistry (bachelor program, CHI501 and CHI601). Some basics in organometallic chemistry will be appreciated.
Course outline:     It is recognized that a large number of bioactive compounds are cyclic molecules containing one or several heteroatoms (N, O, S, …). In this course, the chemical properties of the most representative 6- and 5-membered rings and the major methods used for their synthesis will be reviewed. Especially, methods using organometallic chemistry will be discussed. Nomenclature rules will also be explained and exemplified.
Format of the course: 30h of lectures / 6h of tutorials
Format of exams:  Ongoing assessment and Final written exam (at the end of December)
Skills: Knowledge of the typical reactivity and synthesis methods of the most representative rings using classical and modern heterocyclic chemistry.
Details: 
I. Introduction General presentation and definitions
II. Nomenclature Rules 
III. Structures of Heterocycles Structure-reactivity relationships
IV. Common Reaction Types in Aromatic Heterocyclic Chemistry Electrophilic substitution, Nucleophilic substitution, Organometallic Heterocyclic Chemistry
V. General Strategies for Heterocycle Synthesis
VI. Typical reactivity and Synthesis of 6-membered rings Pyridine, Benzopyridines, Diazines 
VII. Typical reactivity and Synthesis of 5-membered rings Pyrrole, Furan, Thiophene, Azoles and their Benzofused analogs
VIII. Reactivity of Purines A combination of the 6- and 5-membered rings reactivity