UE Molecular Bases of the Normal and Pathological Memory

The goal of this course is to apprehend the latest findings about the cellular and molecular mechanisms of synaptic plasticity and the causes of their impairment in neurodegenerative diseases with a special emphasis on Alzheimer’s disease.

• What makes the electric      signal? The chemical synapse.
• The glutaminergic synaps: plasticity and memory. Regulation of neurotransmitter disease, of post-synaptic currents, modulation of the expression of pre-and post-synaptic receptors.
• Traffic and diffusion of synaptic receptors
• Genetic and molecular causes of Alzheimer’s disease: presinilins, APP, ApoE. Fronto-temporal dementia.