UE Infectious Diseases (part I)

Course outline

Lectures:

1)    Introduction to infectious diseases (1.5 h) CM

2)    Parasites: bases of the pathogenicity and host / parasite interactions

-       Make yourself at home: remodeling of the host cell by Plasmodium falciparum (1.5 h) CM

-       Schistosoma spp (1.5 h) HP

-       Neglected tropical diseases, selected examples:

Leishmanioses (3 h) CM

Lymphatic filariosis or foodborne trematodiases or cysticercosis (1.5 h) CM

3)    Pathogenic bacteria: bases of the pathogenicity and host / bacteria interactions

-       Borrelia burgdorferi, the infectious agent of Lyme disease: evasion from the immune system (1.5 h) ASP

-       Pathogenicity of Vibrio cholerae, the infectious agent of cholera (1.5 h) ASP

-       Gastric ulcer and gastric cancer: the role of Helicobacter pylori (1.5 h) ASP

-       Lung diseases: Pseudomonas aeruginosa or Mycobacterium tuberculosis (1.5 h) CV

-       Pseudomonas aeruginosa: model of experimental evolution (1.5 h) CV

-       Bacteria of the digestive tract: Enterohemorrhagic Escherichia coli, Shigellae, Listeria monocytogenes (3 h) TH

-       Life within a vacuole: Francisella, Salmonella, Chlamydia (3 h) CM

4)    Viruses: bases of the pathogenicity and host cell / virus interactions

-       Negative RNA viruses: Influenza virus, Rabies, Measles, Ebola (7.5 h) RR and MJ

-       Virus and cancers (1.5h) PM

-       HIV-1: life cycle, entry and budding, vaccine development (3 h) WW

Tutorials: 15h

Analysis of scientific publications to illustrate different aspects of the course

Training to the terminal exam: examples of previous exams

Pre-requisites:

-       Basic knowledge in genetics, cell biology, microbiology and biochemistry.

-       No specific knowledge is required in virology or in parasitology.

Targeted skills:

- Knowledge in host-pathogen interactions (models of bacterial, parasitic and viral      infections)

- Ability to analyze biological data from published scientific manuscripts.