UE Integrative structural cell biology

The course aims at introducing the students to advance and modern methods in structural biology that integrate structural and/or dynamical information at different levels of resolution.  

- Structure of large biomolecular assemblies

•  Obtaining key information on large biomolecular assemblies and systems
•  Electron microscopy and tomography
•  NMR spectroscopy
• X-ray and neutron diffraction
• Hybrid approaches (combination of high- and low-resolution structural methods)
•  Structure of ribosome, signal recognition particle, viruses,…

- From macromolecules to the cell

•  High resolution optical microscopy
•  Atomic force microscopy
•  Correlative electron microscopy (combination of optical and electron microscopy)
•  Structure and dynamics of the cytoskeleton
•  Biology of flower …..

- Dynamics of biomolecular systems

•  Dynamics by NMR spectroscopy
•  Neutron spectroscopy
•  Molecular dynamic simulations
• Intrinsically disordered proteins

Understanding concepts, prospects and current problems of integrative structural biology, integrating results from different methods (EM, high-resolution optical microscopy, X-ray, NMR, SAXS/SANS, molecular dynamics simulation and functional data), expertise in electron microscopy reconstruction and in hybrid structural methods, insight into large macromolecular assemblies and macromolecular dynamics.