ECTS
6 crédits
Composante
UFR Chimie-Biologie
Période de l'année
Toute l'année
Description
(Course outline)
The course is organized in three interconnected topics:
1/ Biocatalysis
2/ Oxygen chemistry in Biology
3/ Biochemistry around cellular membranes (membranes lipids and rafts, membrane proteins, and glycosaminoglycans)
Biocatalysis
Basis in Enzymes cofactors and vitamins
Cofactors involved in group transfer
Cofactors involved in redox reaction
Cofactors and chemical origin of life
Biological Chemistry of Oxygen
Chemistry of O2
Defense mechanism, detoxification of reactive oxygen species (ROS)
Role of ROS in physio-pathology
Regulation, sensing mechanism
Cellular sources of ROS.
Membrane Biochemistry
Lipids, Membrane and Rafts
Membrane proteins: synthesis and topology
Membrane proteins and detergent biochemistry
Receptors
Transporters
Channels
Extracellular Biochemistry: GAGs
Extracellulaire matrices
Glycosaminoglycans (GAG): biosynthesis and catabolism
GAG: biological activities
GAG: pathology and applications
This module brings strong background (relative to oxidative stress) to the Unit “Experimental Approaches in Biology”
Heures d'enseignement
- UE Chemistry and Cellular Biochemistry - CMCM30h
- UE Chemistry and Cellular Biochemistry - TDTD20h
Compétences visées
(Targeted skills)
- expertise in structural analysis of an active site
- basics in chemical mechanism occurring in enzymes (as a function of the different types of cofactors)
- characterization of cofactors/active site by biophysical methods.
All these competences are preliminary to future drug design expertise and approaches that will be viewed more deeply in other modules of the master.
- Chemistry and reactivity of O2 in biology (molecular basis of oxydative stress, role in pathology (cancer, etc..); detoxification, ....
- Biochemistry of lipids, lipids rafts, membrane protein biochemistry (receptors, transporters, channels), basis in pharmacology of membrane proteins, and biosynthesis and biology of glycosaminoglycans.