UE Cell compartmentalization and implications in pathology

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Degrees incorporating this pedagocial element :




  • Introduction: sorting proteins      within the cells
  • Sorting and transport of newly      synthesized proteins into endoplasmic reticulum
  • Sorting and transport of newly      synthesized proteins into mitochondria
  • Protein import and export to      and from the nucleus
  • Vesicular traffic
  • Experimental methods
  • Vesicle budding and      selectivity of the cargo and vesicle fission
  • Vesicle fusion: the SNARE/SNAP      system
  • Sorting the vesicles,      tethering molecules
  • Regulation of vesicular      traffic: Bulk transport and retention signals
  • Addressing to the lysosomal      compartment: how to escape from constitutive exocytosis
  • Endocytosis


-       Virus and host Interactions:

  • Virus entry using endosomal machinery
  • Using the ESCORT system for virus budding
  • ER membrane remodeling for virus replication

-       Intracellular parasites, the example of protozoa

  • The parasitophorous vacuole of Toxoplasma gondii: formation and escape mechanisms to cell defense
  • Trypanosoma cruzi/host cell interplay


  • Structure-function      relationship in the cell nucleus: questions and tolls
  • Higher-order genome      organization in the cell nucleus and implication in diseases: cancer,      laminopathies and aging
  • Role of noncoding DNA in      structural and functional organization of the genome
  • Role of nuclear compartments      in transcription and RNA maturation (speckles, PML, Cajal bodies,      nucleoli)


Targeted skills

Understanding how eukaryotic cells build up their organelles and how these mechanisms can be hijacked by viruses and protozoan parasites.