UE Epigenetics and cell differentiation

Diplômes intégrant cet élément pédagogique :

Descriptif

Course outline

Today, the term “epigenetics” is used to describe the study of heritable changes in genome function that occur without a change in DNA sequence. This includes the way gene expression is passed from one cell to its progeny, how gene expression changes during the differentiation of one cell type into another, and how environmental factors can change the way genes are expressed. Epigenetic regulation involves changes of chromatin structure. Interestingly, the mechanisms involved in epigenetic regulation, such as histone modifications, also participate in the transient changes of gene expression.

This course is therefore opened to all students with an interest in the control of gene expression. There are far-reaching implications of epigenetic research for plant and human biology and disease.

The different mechanisms involved in epigenetic regulation, and the different contexts involving epigenetic regulation will be presented:

- actors involved in epigenetic regulation (role of histone modification, chromatin remodeling complex, histone variants, DNA methylation, small and long noncoding RNA),

- contexts involving an epigenetic regulation (response to cell environment, cell differentiation, development)

- implication in diseases.

 

Format of the course

 

Activities

Hours

Percentage

Lectures

20

23%

Tutorials and discussions

15

18%

Lab sessions

no

 

Estimated work load at home

50

59%

Total

85

100%

 

 

Exam requirements

 

Nature of the exams

Mid-term (Number of hours, % of the final grade)

Final (Number of hours, % of the final grade)

Second session

Written exam

2h

60%

 

Oral exam

30 to 45 min

40%

60% (will replace the mark of the written exam)

Research project

 

 

 

Synthesis

 

 

 

Practicals: report

 

 

 

Pré-requis

-Language used for the teaching and evaluation:

English

-To which kind of program can you apply when ta development and Differentiation king this course?

PhD programs in Biology

-Pre-requisites:

A solid formation in the field of transcription is required.

The topics developed in the M1 modules BIO 713 “Molecular Genetics and Epigenetics” and BIO 816 “Development and Differentiation” represent a good introduction to the module.

-Is the number of students limited in this course?

20 students

Compétences visées

-Targeted skills:

* To understand the different biological contexts involving an epigenetic control of transcription as well as the molecular mechanisms, which are involved,

* To understand the different scientific and therapeutic issues of research in epigenetics.

* Capacity to present, within a time limit, a scientific work and the issues at stake

* Acquisition of a solid intellectual formation through scientific questioning.

 

Informations complémentaires

Lieu(x) : Grenoble - Domaine universitaire
Langue(s) : Anglais