UE Bio-Organic and Inorganic Chemistry

Degrees incorporating this pedagocial element :

Description

This course introduces the structure and reactivity of different classes of biomolecules (peptides, nucleic acids) with a special emphasis on their synthetic pathway. An overview of the roles that are played by the metal ions in life (biotransformations, dioxygen transport, drug elimination, toxicity…) will then be presented. A third aspect will be developed, the medicinal chemistry of inorganic compounds, used in diagnosis (contrast agents), chemotherapy (cis-platinum) and radiotherapy (Tc complexes). Finally, we will focus on the MRI techniques used world-wide for imaging tissues.

Prerequisites

Inorganic Chemistry (bachelor program, CHI502), Chemistry of Biomolecules (CHI735)

Targeted skills

Knowledge of the role of the metal ions in biology and medicine / Chemical reactivity and methods of synthesis of nitrogen containing heterocycles

Bibliography

I. Bioinorganic section:
1. Dedicated spectroscopic tools
2. Structuration and biomineralization
3. Dioxygen transport
4. Biotransformations (various oxidations, hydrolysis …)
5. Electron transfer
6. Regulation of metal concentration (iron)
7. Inorganic chemistry for medicine
8. Metals and DNA

II. Bioorganic chemistry
1. Pyridine and benzopyridine derivatives
2. Pyrrole and indole derivatives
3. Pyrimidine derivatives
4. Purines
5. Nucleosides
6. Oligonucleotides