Degrees incorporating this pedagocial element :
Description
This course introduces the structure and reactivity of different classes of biomolecules (peptides, nucleic acids) with a special emphasis on their synthetic pathway. An overview of the roles that are played by the metal ions in life (biotransformations, dioxygen transport, drug elimination, toxicity…) will then be presented. A third aspect will be developed, the medicinal chemistry of inorganic compounds, used in diagnosis (contrast agents), chemotherapy (cis-platinum) and radiotherapy (Tc complexes). Finally, we will focus on the MRI techniques used world-wide for imaging tissues.
Prerequisites
Inorganic Chemistry (bachelor program, CHI502), Chemistry of Biomolecules (CHI735)
Targeted skills
Knowledge of the role of the metal ions in biology and medicine / Chemical reactivity and methods of synthesis of nitrogen containing heterocycles
Bibliography
I. Bioinorganic section:
1. Dedicated spectroscopic tools
2. Structuration and biomineralization
3. Dioxygen transport
4. Biotransformations (various oxidations, hydrolysis …)
5. Electron transfer
6. Regulation of metal concentration (iron)
7. Inorganic chemistry for medicine
8. Metals and DNA
II. Bioorganic chemistry
1. Pyridine and benzopyridine derivatives
2. Pyrrole and indole derivatives
3. Pyrimidine derivatives
4. Purines
5. Nucleosides
6. Oligonucleotides
In brief
Period : Semester 8Credits : 6
Number of hours Lectures (CM) : 37h
Number of hours Tutorial (TD) :13h
Culmination Code (APOGEE) : YACH8U23
Location(s) : Grenoble - University campus
Language(s) : English
Contacts
Fabrice THOMAS
